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J Neurophysiol 98: 3221-3229, 2007. First published October 17, 2007; doi:10.1152/jn.00857.2007
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Discharge of the Readily Releasable Pool With Action Potentials at Hippocampal Synapses

Charles F. Stevens1 and James H. Williams1,2

1Molecular Neurobiology Lab, The Salk Institute, La Jolla, California; and 2Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts

Submitted 2 August 2007; accepted in final form 11 October 2007

A readily releasable pool (RRP) of synaptic vesicles has been identified at hippocampal synapses with application of hypertonic solution. RRP size correlates with important properties of synaptic function such as release probability. However, a discrepancy in RRP size has been reported depending on the method used to evoke synaptic release. This study was undertaken to determine quantitative relationships between the RRP defined with hypertonic solution and that released with trains of action potentials. We find that asynchronous release at cell culture synapses contributes significantly to the discharge of the RRP with trains of action potentials and that RRP size is the same when elicited by either nerve stimuli or hypertonic challenge.

Address for reprint requests and other correspondence: C. F. Stevens, Molecular Neurobiology Lab, The Salk Institute, 10010 N. Torrey Pines Rd., La Jolla, CA 92037 (E-mail: cfs{at}salk.edu)




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