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J Neurophysiol 99: 787-798, 2008. First published November 28, 2007; doi:10.1152/jn.00658.2007
0022-3077/08 $8.00
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Fine Detail of Neurovascular Coupling Revealed by Spatiotemporal Analysis of the Hemodynamic Response to Single Whisker Stimulation in Rat Barrel Cortex

J. Berwick, D. Johnston, M. Jones, J. Martindale, C. Martin, A. J. Kennerley, P. Redgrave and J.E.W. Mayhew

Department of Psychology, University of Sheffield, Sheffield, United Kingdom

Submitted 14 June 2007; accepted in final form 26 November 2007

The spatial resolution of hemodynamic-based neuroimaging techniques, including functional magnetic resonance imaging, is limited by the degree to which neurons regulate their blood supply on a fine scale. Here we investigated the spatial detail of neurovascular events with a combination of high spatiotemporal resolution two-dimensional spectroscopic optical imaging, multichannel electrode recordings and cytochrome oxidase histology in the rodent whisker barrel field. After mechanical stimulation of a single whisker, we found two spatially distinct cortical hemodynamic responses: a transient response in the "upstream" branches of surface arteries and a later highly localized increase in blood volume centered on the activated cortical column. Although the spatial representation of this localized response exceeded that of a single "barrel," the spread of hemodynamic activity accurately reflected the neural response in neighboring columns rather than being due to a passive "overspill." These data confirm hemodynamics are capable of providing accurate "single-condition" maps of neural activity.

Address for reprint requests and other correspondence: J. Berwick, Dept. of Psychology, University of Sheffield, Sheffield S10 2TN, UK (E-mail: j.berwick{at}sheffield.ac.uk)




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H. Ma, M. Zhao, M. Suh, and T. H. Schwartz
Hemodynamic Surrogates for Excitatory Membrane Potential Change During Interictal Epileptiform Events in Rat Neocortex
J Neurophysiol, May 1, 2009; 101(5): 2550 - 2562.
[Abstract] [Full Text] [PDF]


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