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Letter to the Editor
) mentions the presence of ipsilateral corticospinal innervation in humans on several occasions (for example in p. 2416) despite the ubiquitous occurrence of onset asynchrony (of 
150 ms) in their controls—leaving the functional status (relevance) of such fibers (if they exist) in limbo. Neither have they committed themselves as to the reason for the onset asynchrony so nicely depicted in Fig. 8 of the article. The reason, I believe, is paucity of clinical perspective in such studies as follows: the essential feature requiring an explanation, not forthcoming from the doctrine of contralateral innervation (followed by the authors), is the asymmetry of signs and symptoms in patients with comparable lesions affecting the major and minor hemispheres. It is only natural to wonder if such an asymmetry is related to the persistent asymmetry of the reaction time documented in the control subjects of their study. Elsewhere I have shown in detail that the two are related and that the link is coded in the (neural) handedness of humans (Derakhshan 2003a,b). Thus the reason for the inescapable onset asynchrony of their subjects is the callosum-length proximity of the command center to the dominant hand of their subjects as compared with the nondominant, which is connected to the same command via the corpus callosum. This nondominant delay is the interhemispheric transfer time, which varies with the "tempo" of the activity; a fact known to musicologists as the melody lead of the right hand (in right-handed pianists) (Vernon 1936). Liepmann depicted this callosally mediated relationship (delay) in two of his articles, carrying the "movement formula" from the major to the minor hemisphere (Liepmann 1900, 1920) (Fig. 1).
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). Others have referred to the same as "the impossibility of humans generating multiple independent, unsynchronized parallel action plans for the two hands" (Laeng and Park 1999) or have simply called it "synchronization error" (Kristeva and Deecke 1979). REFERENCES
Derakhshan I. Callosum and movement control: case reports. Neurol Res 25: 538-542, 2003a.[CrossRef][Web of Science][Medline]
Derakhshan I. In defense of the sinistrals: anatomy of handedness and the safety of prenatal ultrasound. Ultrasound Obstet Gynecol 21: 209-212, 2003b.[CrossRef][Web of Science][Medline]
Derakhshan I. Facilitation of motor evoked potentials and H-reflexes of flexor carpi radialis muscle induced by voluntary teeth clenching (comments on Sugawara and Kasai 2002). Hum Mov Sci 21: 203-212, 2003c.
Diedrichsen J, Hazeltine E, Nurss WK, and Ivry RB. The role of the corpus callosum in the coupling of bimanual isometric force pulses. J Neurophysiol 90: 2409-2418, 2003.
Hazeltine E, Diedrichsen J, Kennerley SW, and Ivry RB. Bimanual cross-talk during reaching movements is primarily related to response selection, not the specification of motor parameters. Psychol Res 67: 56-70, 2003.[Web of Science][Medline]
Kristeva R, Keller E, Deecke L, and Kornhuber HH. Cerebral potentials preceding unilateral and simultaneous bilateral finger movements. Electroencephalogr Clin Neurophysiol 47: 229-238, 1979.[CrossRef][Web of Science][Medline]
Laeng B and Park A. Handedness effect on playing a reversed or normal key board. Laterality 4: 363-377, 1999.[CrossRef][Medline]
Liepmann H. Das Krankheitsbild der Apraxia (<<motorischen Asymbolie>>) auf Grund eines Falles von einseitiger Apraxie. Mschr Psychiat Neurol 8: 15-44, 102-132, 188-197, 1900.
Liepmann H. Apraxie. In: Real-Encyclopedi
der Gesamten Heilkunde. Ergebnisse der Gesamten Medizin, edited by Brugsch T and Eulenburg A. Berlin: Urban and Schwarzenberg, 1920, vol. 1, p. 116-143.
Vernon LN. 1936. Synchronization of chords in artistic piano music. In. Studies in Psychology of Music, edited by Seashore CE. Iowa City, IA: University Press, 1963, vol. 3, p. 306-345.
Iraj Derakhshan
415 Morris St., #401
Charleston, WV 25301
). Before turning to the interesting issues regarding hemispheric asymmetries and how they may relate to our study, we wish to point out that his concern about the status of ipsilateral fibers is based on a misunderstanding of the data. Onset asynchronies of 150 ms are by no means "ubiquitous." When we restricted the analysis of the data to the shorter half of the onset asynchronies, the correlation between produced forces remained strongly reduced in callosotomy patients (see Fig. 8). In our opinion, these data are inconsistent with the hypothesis that force coupling is the result of activation from ipsilateral, descending fibers because the neural activity of ipsilateral and contralateral fibers would have strongly overlapped for these responses.
More interesting is I. Derakshan's review of the hypothesis that motor behavior for both hands is mainly controlled by the dominant hemisphere. This hypothesis is supported by a wealth of lesion studies indicating that chronic symptoms of apraxia are usually associated with left-hemisphere damage (for a review, Leiguarda and Marsden 2000). Moreover, neuroimaging (Kim et al. 1993) and TMS (Chen et al. 1997) studies also suggest an asymmetric role for the left hemisphere in motor control.
However, we do not believe that the temporal asynchronies in our study provide evidence for the unilateral control hypothesis as suggested by I. Derakshan. If the temporal asynchronies stemmed from the dominance of the left hemisphere and its producing the motor commands for both hands, then we should have observed a consistent right-hand lead (all of our control participants were right-handed). However, half the participants showed a consistent left-hand lead and the other participants a consistent right-hand lead (p. 2414). Data from other studies also suggest that phase leads during bimanual actions may be a much more complex phenomenon than suggested by the mechanistic explanation offered in I. Derakshan's letter. Temporal lags can be highly influenced by the allocation of attention and other factors (Franz et al. 2002; Swinnen et al. 1996). Moreover, during simple finger tapping movements, no temporal asynchronies are typically observed in healthy controls (e.g., Ivry and Hazeltine 1999). These findings present a challenge to I. Derakshan's simplified version of a unilateral control hypothesis.
While it is likely that asymmetric functions between the two hemispheres emerge at higher levels of the human motor system, the two hands also can exhibit surprising independence of control, for example, during visually guided aiming movements (Diedrichsen et al. 2001, 2004). Elucidation of the interplay between unilateral control and bilateral coordination remains an important goal of further study of the human motor system.
REFERENCES
Chen R, Gerloff C, Hallett M, and Cohen LG. Involvement of the ipsilateral motor cortex in finger movements of different complexities. Ann Neurol 41: 247-254, 1997.[CrossRef][Web of Science][Medline]
Diedrichsen J, Hazeltine E, Kennerley S, and Ivry RB. Moving to directly cued locations abolishes spatial interference during bimanual actions. Psychol Sci 12: 493-498, 2001.[CrossRef][Web of Science][Medline]
Diedrichsen J, Hazeltine E, Nurss WK, and Ivry RB. The role of the corpus callosum in the coupling of bimanual isometric force pulses. J Neurophysiol 90: 2409-2418, 2003.
Diedrichsen J, Nambisan R, Kennerley S, and Ivry RB. Independent on-line control of the two hands during bimanual reaching. Eur J Neurosci In press.
Franz EA, Rowse A, and Ballantine B. Does handedness determine which hand leads in a bimanual task? J Mot Behav 34: 402-412, 2002.[Web of Science][Medline]
Ivry RB and Hazeltine E. Subcortical locus of temporal coupling in the bimanual movements of a callosotomy patient. Hum Mov Sci 18: 345-375, 1999.[CrossRef]
Kim SG, Ashe J, Hendrich K, Ellermann JM, Merkle H, Uagurbil K, and Georgopoulos AP. Functional magnetic resonance imaging of motor cortex: hemispheric asymmetry and handedness. Science 261: 615-617, 1993.
Leiguarda RC and Marsden CD. Limb apraxias: higher-order disorders of sensorimotor integration. Brain 123: 860-879, 2000.
Swinnen SP, Jardin K, and Meulenbroek R. Between-limb asynchronies during bimanual coordination: effects of manual dominance and attentional cueing. Neuropsychologia 34: 1203-1213, 1996.[CrossRef][Web of Science][Medline]
Jörn Diedrichsen
Eliot Hazeltine
Richard B. Ivry
Department of Biomedical Engineering
Johns Hopkins University
Baltimore, MD 21205-2195
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