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J Neurophysiol (April 16, 2008). doi:10.1152/jn.00002.2008
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Submitted on January 2, 2008
Accepted on April 13, 2008

Corticofugal Projection Inhibits the Auditory Thalamus through the Thalamic Reticular Nucleus

Zhuo Zhang1, Chun-Hua Liu2, Yan-Qin Yu3, Kenji Fujimoto4, Ying-Shing Chan5, and Jufang He1*

1 Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong
2 Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, Hong Kong; Department of Physiology and Research Centre of Heart, Brain, Hormone and Healthy Aging, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong
3 Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, Hong Kong; Department of Physiology, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China
4 Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, Hong Kong
5 Department of Physiology, and Research Centre of Heart, Brain, Hormone and Healthy Aging, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong

* To whom correspondence should be addressed. E-mail: rsjufang{at}polyu.edu.hk.

Electrical stimulation of the auditory cortex (AC) causes both facilitatory and inhibitory effects on the medial geniculate body (MGB). The purpose of this study was to identify the corticofugal inhibitory pathway to the MGB. We assessed two potential circuits: 1) the cortico-colliculo-thalamic circuit and 2) cortico-reticulo-thalamic one. We compared intracellular responses of MGB neurons to electrical stimulation of the AC following bilateral ablation of the inferior colliculi (IC) or thalamic reticular nucleus (TRN) in anesthetized guinea pigs. Cortical stimulation with intact TRN could cause strong inhibitory effects on the MGB neurons. The corticofugal inhibition remained effective after bilateral IC ablation, but it was minimized after the TRN was lesioned with kainic acid. Synchronized TRN neuronal activity and MGB IPSPs was observed with multiple recordings. The results suggest that corticofugal inhibition traverses the corticoreticulothalamic pathway, indicating that the colliculi-geniculate inhibitory pathway is probably only for feedforward inhibition.






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