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J Neurophysiol (February 7, 2007). doi:10.1152/jn.00013.2007
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Submitted on January 5, 2007
Accepted on February 3, 2007

Facilitating sensory responses in developing mouse somatosensory barrel cortex

Aren Jacobus Borgdorff1, James FA Poulet1, and Carl CH Petersen1*

1 Laboratory of Sensory Processing, Brain Mind Institute, Lausanne, Switzerland

* To whom correspondence should be addressed. E-mail: carl.petersen{at}epfl.ch.

The sensory responses in the barrel cortex of mice aged postnatal day (P) 7-12 evoked by a single whisker deflection are smaller in amplitude and spread over a smaller area than those measured in P13-21 mice. However, repetitive 10Hz stimulation or paired pulse whisker stimulation in P7-12 mice evoked facilitating sensory responses, contrasting with the depressing sensory responses observed in P13-21 mice. This facilitation occurred during an interval ranging 300-1000ms following the first stimulus and was measured using whole-cell recordings, voltage-sensitive dye imaging and calcium-sensitive dye imaging. The facilitated responses were not only larger in amplitude but also propagated over a larger cortical area. The facilitation could be blocked by local application of pharmacological agents reducing cortical excitability. Local cortical microstimulation could substitute for the first whisker stimulus to produce a facilitated sensory response. The enhanced sensory responses upon repetitive sensory stimuli in P7-12 mice may contribute to the activity-dependent specification of the developing cortical circuits. In addition, the facilitating sensory responses allow long integration times for sensory processing compatible with the slow behavior of mice during early postnatal development.




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