| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Program in Neuroscience, Wake Forest Univ. School of Medicine, Winston-Salem, NC, USA
2 Neurobiology and Anatomy, Wake Forest Univ. School of Medicine, Winston-Salem, NC, USA
* To whom correspondence should be addressed. E-mail: stanford{at}wfubmc.edu.
This study investigates the visuomotor properties of several nuclei within primate central thalamus. These nuclei, which might be considered components of an oculomotor thalamus (OcTh) are found within and at the borders of the internal medullary lamina (IML). These nuclei have extensive anatomical links to numerous cortical and subcortical visuomotor areas including the frontal eye fields (FEF), supplementary eye fields (SEF), prefrontal cortex (PFC), posterior parietal cortex (PPC), caudate, and substantia nigra pars reticulata (SNr). Previous single-unit recordings have shown that neurons in OcTh respond during self-paced spontaneous saccades and to visual stimuli in the absence of any specific behavioral requirement, but a thorough account of the activity of these areas in association with voluntary, goal-directed movement is lacking. We recorded activity from single neurons in primate central thalamus during performance of a visually-guided delayed saccade task. The sample consisted primarily of neurons from the central lateral (CL) and paracentral (Pc) intralaminar nuclei and paralaminar regions of the ventral anterior (VA) and ventral lateral (VL) nuclei. Neurons responsive to sensory, delay, and motor phases of the task were observed in each region, with many neurons modulated during multiple task periods. Across the population, variation in the quality and timing of saccade-contingent activity suggested participation in functions ranging from generating a saccade (pre-saccadic) to registering its consequences (e.g. efference copy). Finally, many neurons were found to carry spatial information during the delay period suggesting a role for central thalamus in higher-order aspects of visuomotor control.
This article has been cited by other articles:
|
|
 |
|
  M. Tanaka Cognitive Signals in the Primate Motor Thalamus Predict Saccade Timing J. Neurosci., October 31, 2007; 27(44): 12109 - 12118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tanaka Spatiotemporal Properties of Eye Position Signals in the Primate Central Thalamus Cereb Cortex, July 1, 2007; 17(7): 1504 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Park, M. Schlag-Rey, and J. Schlag Frames of Reference for Saccadic Command Tested By Saccade Collision in the Supplementary Eye Field J Neurophysiol, January 1, 2006; 95(1): 159 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Simo, C. M. Krisky, and J. A. Sweeney Functional Neuroanatomy of Anticipatory Behavior: Dissociation between Sensory-driven and Memory-driven Systems Cereb Cortex, December 1, 2005; 15(12): 1982 - 1991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tanaka Involvement of the Central Thalamus in the Control of Smooth Pursuit Eye Movements J. Neurosci., June 22, 2005; 25(25): 5866 - 5876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bellebaum, I. Daum, B. Koch, M. Schwarz, and K.-P. Hoffmann The role of the human thalamus in processing corollary discharge Brain, May 1, 2005; 128(5): 1139 - 1154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Tanibuchi and P. S. Goldman-Rakic Comparison of Oculomotor Neuronal Activity in Paralaminar and Mediodorsal Thalamus in the Rhesus Monkey J Neurophysiol, January 1, 2005; 93(1): 614 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Watanabe and S. Funahashi Neuronal Activity Throughout the Primate Mediodorsal Nucleus of the Thalamus During Oculomotor Delayed-Responses. I. Cue-, Delay-, and Response-Period Activity J Neurophysiol, September 1, 2004; 92(3): 1738 - 1755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Watanabe and S. Funahashi Neuronal Activity Throughout the Primate Mediodorsal Nucleus of the Thalamus During Oculomotor Delayed-Responses. II. Activity Encoding Visual Versus Motor Signal J Neurophysiol, September 1, 2004; 92(3): 1756 - 1769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Wyder, D. P. Massoglia, and T. R. Stanford Contextual Modulation of Central Thalamic Delay-Period Activity: Representation of Visual and Saccadic Goals J Neurophysiol, June 1, 2004; 91(6): 2628 - 2648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Sommer and R. H. Wurtz What the Brain Stem Tells the Frontal Cortex. I. Oculomotor Signals Sent From Superior Colliculus to Frontal Eye Field Via Mediodorsal Thalamus J Neurophysiol, March 1, 2004; 91(3): 1381 - 1402. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
