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J Neurophysiol (March 29, 2006). doi:10.1152/jn.00075.2006
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00075.2006v1
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Submitted on January 23, 2006
Accepted on March 5, 2006

Spike-frequency adaptation and intrinsic properties of an identified, looming-sensitive neuron

Fabrizio Gabbiani1* and Holger G Krapp2

1 Neuroscience, Baylor College of Medicine, Houston, Texas, United States; Computational and Applied Mathematics, Rice University, Houston, Texas, United States
2 Zoology, Cambridge University, Cambridge, United Kingdom; Bioengineering, Imperial College, London, United Kingdom

* To whom correspondence should be addressed. E-mail: gabbiani{at}bcm.edu.

We investigated in vivo the characteristics of spike-frequency adaptation and the intrinsic membrane properties of an identified, looming-sensitive interneuron of the locust optic lobe, the lobula giant movement detector (LGMD). The LGMD had an input resistance of 4-5 M{Omega}, a membrane time constant of ~8 ms and exhibited inward rectification and rebound spiking following hyperpolarizing current pulses. Responses to depolarizing current pulses revealed the neuron's intrinsic bursting properties and pronounced spike-frequency adaptation. The characteristics of adaptation, including its time course, the attenuation of the firing rate, the mutual dependence of these two variables, and their dependence on injected current, followed closely the predictions of a model first proposed to describe the adaptation of cat visual cortex pyramidal neurons in vivo. Our results thus validate the model in an entirely different context and suggest that it might be applicable to a wide variety of neurons across species. Spike-frequency adaptation is likely to play an important role in tuning the LGMD and in shaping the variability of its responses to visual looming stimuli.




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