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J Neurophysiol (May 24, 2006). doi:10.1152/jn.00088.2006
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00088.2006v1
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Submitted on January 26, 2006
Accepted on May 11, 2006

An amperometric study of the kinetics of exocytosis in mouse adrenal slice chromaffin cells: physiological and methodological insights

Gloria Arroyo1, Jorge Fuentealba1, Natalia Sevane-Fernandez2, Marcos Aldea1, Antonio G Garcia1, and Almudena Albillos1*

1 Instituto Teofilo Hernando. Departamento de Farmacologia y Terapeutica, Universidad Autonoma de Madrid, Madrid, Spain
2 Instituto Teofilo Hernando, Departamento de Farmacologia y Terapeutica,, Universidad Autonoma de Madrid, Madrid, Madrid, Spain

* To whom correspondence should be addressed. E-mail: almudena.albillos{at}uam.es.

This study was designed to examine the kinetics of neurotransmitter release using the carbon fiber amperometric technique on cells in slices of mouse adrenal glands superfused with bicarbonate phosphate buffer-based solutions. The exocytotic amperometric response evoked by electrical stimulation was significantly faster than that produced after exogenous application of ACh or K+. Splanchnic nerve-evoked neurotransmitter release was blocked by hexamethonium, indicating the involvement of ACh nicotinic receptors. We discuss the implications of our data for understanding the mechanisms underlying the vesicle fusion process.




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