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J Neurophysiol (August 27, 2003). doi:10.1152/jn.00094.2003
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Submitted on January 31, 2003
Accepted on August 21, 2003

Postural Muscle Responses to Multidirectional Translations in Patients with Parkinson's Disease

Diana Dimitrova1, Fay B. Horak2*, and John G. Nutt3

1 Neurological Sciences Institute, Oregon Health & Science University, Beaverton, OR, USA
2 Neurological Sciences Institute, Oregon Health & Science University, Beaverton, OR, USA; Dept. of Neurology, Oregon Health & Science University, Portland, OR, USA
3 Dept. of Neurology, Oregon Health & Science University, Portland, OR, USA

* To whom correspondence should be addressed. E-mail: horakf{at}ohsu.edu.

The postural inflexibility and somatosensory integration impairments of patients with Parkinsons disease (PD) suggest that the basal ganglia may be important for quickly modifying muscle activation patterns when the direction of perturbation or stance conditions suddenly change. In the present study, we test this hypothesis by comparing the patterns of leg and trunk muscle activation in13 subjects with PD and 13 control subjects in response to 8 randomly-presented directions of horizontal surface translations while standing with either narrow or wide stance. The direction of maximum activation for each muscle was similar for PD and control subjects. However antagonist muscle activation was earlier and larger in PD than in control subjects, resulting in co-activation. PD subjects also did not increase the magnitude of muscle activation as much as did control subjects when changing from wide to narrow stance. These results are consistent with the hypothesis that PD results in an inability to shape the pattern and magnitude of postural muscle responses for changes in perturbation direction and in stance position.




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