JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Neurophysiol (May 25, 2005). doi:10.1152/jn.00175.2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
94/3/2045    most recent
00175.2005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Quevedo, J.
Right arrow Articles by McCrea, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Quevedo, J.
Right arrow Articles by McCrea, D. A.
Submitted on February 18, 2005
Accepted on May 21, 2005

The stumbling corrective reaction during fictive locomotion in the cat

Jorge Quevedo1, Katinka Stecina2, Simon Gosgnach3, and David A. McCrea2*

1 Department of Physiology, Biophysics and Neuroscience, CINVESTAV del IPN, Mexico City, Mexico, Mexico
2 Spinal Cord Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada
3 Molecular Neurobiology Laboratory, The Salk Institute, San Diego, California, USA

* To whom correspondence should be addressed. E-mail: dave{at}scrc.umanitoba.ca.

An obstacle contacting the dorsal surface of a cat's hind foot during the swing phase of locomotion evokes a reflex (the stumbling corrective reaction) that lifts the foot and extends the ankle to avoid falling. We show that the same sequence of ipsilateral hindlimb motoneuron activity can be evoked in decerebrate cats during fictive locomotion. As recorded in the peripheral nerves, twice threshold intensity stimulation of the cutaneous superficial peroneal (SP) nerve during the flexion phase produced a very brief excitation of ankle flexors (e.g. tibialis anterior and peroneus longus) that was followed by an inhibition for the duration of the stimulus train (10-25 shocks, 200 Hz). Extensor digitorum longus was always, and hip flexor (sartorius) activity was sometimes inhibited during SP stimulation. At the same time knee flexor, and the normally quiescent ankle extensor motoneurons, were recruited (mean latencies 4 and 16 ms) with SP stimulation during fictive stumbling correction. Following the stimulus train, ankle extensor activity fell silent and there was an excitation of hip, knee and ankle flexors. The ongoing flexion phase was often prolonged. Hip extensors were also recruited in some fictive stumbling trials. Only the SP nerve was effective in evoking stumbling correction. Delivered during extension, SP stimulus trains increased ongoing extensor motoneuron activity as well as increasing ipsilateral hip, knee and ankle hindlimb flexor activity in the subsequent step cycle. The fictive stumbling corrective reflex appears functionally similar to that evoked in intact, awake animals and involves a fixed pattern of short-latency reflexes as well as actions evoked through the lumbar circuitry responsible for the generation of rhythmic alternating locomotion.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
W. J. Kargo and S. F. Giszter
Individual Premotor Drive Pulses, Not Time-Varying Synergies, Are the Units of Adjustment for Limb Trajectories Constructed in Spinal Cord
J. Neurosci., March 5, 2008; 28(10): 2409 - 2425.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Frigon and S. Rossignol
Short-Latency Crossed Inhibitory Responses in Extensor Muscles During Locomotion in the Cat
J Neurophysiol, February 1, 2008; 99(2): 989 - 998.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. E. Balter and E. P. Zehr
Neural Coupling Between the Arms and Legs During Rhythmic Locomotor-Like Cycling Movement
J Neurophysiol, February 1, 2007; 97(2): 1809 - 1818.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. A. McVea and K. G. Pearson
Long-Lasting, Context-Dependent Modification of Stepping in the Cat After Repeated Stumbling-Corrective Responses
J Neurophysiol, January 1, 2007; 97(1): 659 - 669.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
I. A. Rybak, K. Stecina, N. A. Shevtsova, and D. A. McCrea
Modelling spinal circuitry involved in locomotor pattern generation: insights from the effects of afferent stimulation
J. Physiol., December 1, 2006; 577(2): 641 - 658.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. L. Boothe, A. H. Cohen, and T. W. Troyer
Temporal Correlations in Stochastic Models of Double Bursting During Simulated Locomotion
J Neurophysiol, March 1, 2006; 95(3): 1556 - 1570.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
K. Stecina, J. Quevedo, and D. A. McCrea
Parallel reflex pathways from flexor muscle afferents evoking resetting and flexion enhancement during fictive locomotion and scratch in the cat
J. Physiol., November 15, 2005; 569(1): 275 - 290.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. Quevedo, K. Stecina, and D. A. McCrea
Intracellular Analysis of Reflex Pathways Underlying the Stumbling Corrective Reaction During Fictive Locomotion in the Cat
J Neurophysiol, September 1, 2005; 94(3): 2053 - 2062.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2005 by the The American Physiological Society.