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J Neurophysiol (April 30, 2003). doi:10.1152/jn.00190.2003
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Submitted on February 27, 2003
Accepted on April 23, 2003

A Minimal Model for G Protein-Mediated Synaptic Facilitation and Depression

Richard Bertram1*, Jessica Swanson2, Mohammad Yousef3, Zhong-Ping Feng4, and Gerald W. Zamponi4

1 Department of Mathematics, Florida State University, Tallahassee, Florida, USA; Kasha Institute of Biophysics, Florida State University, Tallahassee, Florida, USA
2 Department of Mathematics, Florida State University, Tallahassee, Florida, USA
3 Kasha Institute of Biophysics, Florida State University, Tallahassee, Florida, USA
4 Departments of Physiology and Biophysics and of Pharmacology and Therapeutics, Cellular and Molecular Neurobiology Research Group, University of Calgary, Calgary, Alberta, Canada

* To whom correspondence should be addressed. E-mail: bertram{at}math.fsu.edu.

G protein-coupled receptors are ubiquitous in neurons, as well as other cell types. Activation of receptors by hormones or neurotransmitters splits the G protein heterotrimer into G{alpha} and G{beta}{gamma} subunits. It is now clear that G{beta}{gamma} directly inhibits Ca2+ channels, putting them into a reluctant state. The effects of G{beta}{gamma} depend on the specific {beta} and {gamma} subunits present, as well as the {beta} isoform of the N-type Ca2+ channel. We describe a minimal mathematical model for the effects of G protein action on the dynamics of synaptic transmission. The model is calibrated by data obtained by transfecting G protein and Ca2+ channel subunits into tsA-201 cells. We demonstrate with numerical simulations that G protein action can provide a mechanism for either short-term synaptic facilitation or depression, depending on the manner in which G protein-coupled receptors are activated. The G protein action performs high-pass filtering of the presynaptic signal, with a filter cutoff that depends on the combination of G protein and Ca2+ channel subunits present. At stimulus frequencies above the cutoff trains of single spikes are transmitted, while only doublets are transmitted at frequencies below the cutoff. Finally, we demonstrate that relief of G protein inhibition can contribute to paired-pulse facilitation.




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