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J Neurophysiol (May 28, 2003). doi:10.1152/jn.00200.2003
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Submitted on March 3, 2003
Accepted on May 27, 2003

Sustained muscle contractions maintained by autonomous neuronal activity within the human spinal cord

Daichi Nozaki1*, Noritaka Kawashima1, Yu Aramaki2, Masami Akai1, Kimitaka Nakazawa1, Yasoichi Nakajima2, and Hideo Yano1

1 Department of Motor Dysfunction, Research Institute of National Rehabilitation Center for the Disabled, Tokorozawa, Japan
2 Department of Sensory & Communication Disorders, Research Institute of National Rehabilitation Center for the Disabled, Tokorozawa, Japan

* To whom correspondence should be addressed. E-mail: dnozaki{at}rehab.go.jp.

It is well known that muscle contraction can be easily evoked in the human soleus muscle by applying single pulse electrical stimulation to the tibial nerve at the popliteal fossa. We herein reveal the unexpected phenomenon of muscle contractions that can be observed when train stimulation is used instead. We found, in 11 human subjects, that transient electrical train stimulation (1msec pulses, 50Hz, 2sec) was able to induce sustained muscle contractions in the soleus muscle that outlasted the stimulation period for greater than one minute. Subjects were unaware of their own muscle activity, suggesting that this is an involuntary muscle contraction. In fact, the excitability of the primary motor cortex (M1) with the sustained muscle contractions evaluated by transcranial magnetic stimulation was lower than the excitability with voluntary muscle contractions even when both muscle contraction levels were matched. This finding indicates that M1 was less involved in maintaining the muscle contractions. Furthermore, the muscle contractions did not come from spontaneous activity of muscle fibers or from reverberating activity within closed neuronal circuits involving motoneurons. These conclusions were made based on the respective evidence: (i) the electromyographic activity was inhibited by stimulation of the common peroneal nerve that has inhibitory connections to the soleus motoneuron pool and (ii) it was not abolished after stopping the reverberation (if any) for approximately 100msec by inducing the silent period that followed an H-reflex. These findings indicate that the sustained muscle contractions induced in this study are most likely to be maintained by autonomous activity of motoneurons and/or interneurons within the human spinal cord.




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