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J Neurophysiol (April 14, 2004). doi:10.1152/jn.00202.2004
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Submitted on March 2, 2004
Accepted on April 7, 2004

Dopamine-induced Dispersion of Correlations Between Action Potentials in Networks of Cortical Neurons

Danny Eytan1, Amir Minerbi2, Noam E. Ziv2, and Shimon Marom1*

1 Department of Physiology and Biophysics, Faculty of Medicine, Technion, Haifa, Israel
2 Department of Anatomy and Cell Biology, Faculty of Medicine, Technion, Haifa, Israel

* To whom correspondence should be addressed. E-mail: marom{at}tx.technion.ac.il.

The involvement of dopamine in the process of learning, at the cellular and behavioural levels, has been studied extensively. Evidently, dopamine is released from midbrain nuclei neurons upon exposure to salient unpredicted stimuli, and binds to neurons of cortical and subcortical structures, where its neuromodulatory effects are exerted. The neuromodulatory effects of dopamine at the synaptic and cellular levels are very rich, but it is difficult to extrapolate from these elementary levels what their effect might be at the behaviourally relevant level of neuronal ensembles. Using multi-site recordings from networks of cortical neurons developing ex-vivo, we studied the effects of dopamine on connectivity within neuronal ensembles. We found that dopamine disperses correlations between individual neuronal activities, while preserving the global distribution of correlations at the network level. Using selective D1 and D2 modulators we show that both receptor types are contributing to dopamine-induced dispersion. Our results indicate that at the neuronal ensemble level, dopamine acts to enhance changes in network connectivity rather than stabilize such connections.




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