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J Neurophysiol (May 9, 2007). doi:10.1152/jn.00252.2007
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Submitted on March 6, 2007
Accepted on May 4, 2007

Dissociation of eye and head components of gaze shifts by stimulation of the omnipause neuron region

Neeraj J Gandhi1* and David L Sparks2

1 Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
2 Neuroscience, Baylor College of Medicine, Houston, Texas, United States

* To whom correspondence should be addressed. E-mail: neg8{at}pitt.edu.

Natural movements often include actions integrated across multiple effectors. Coordinated eye-head movements are driven by a command to shift the line of sight by a desired displacement vector. Yet, because extraocular and neck motoneurons are separate entities, the gaze shift command must be separated into independent signals for eye and head movement control. We report that this separation occurs, at least partially, at or before the level of pontine omnipause neurons (OPNs). Stimulation of the OPNs prior to and during gaze shifts temporally decoupled the eye and head components by inhibiting gaze and eye saccades. In contrast, head movements were consistently initiated before gaze onset, and ongoing head movements continued along their trajectories, albeit with some characteristic modulations. After stimulation offset, a gaze shift composed of an eye saccade and a reaccelerated head movement was produced to preserve gaze accuracy. We conclude that signals subject to OPN inhibition produce the eye movement component of a coordinated eye-head gaze shift and are not the only signals involved in the generation of the head component of the gaze shift.




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