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J Neurophysiol (July 27, 2005). doi:10.1152/jn.00264.2005
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00264.2005v1
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Submitted on March 11, 2005
Accepted on July 17, 2005

Signal Propagation along Uni-dimensional Neuronal Networks

Ofer Feinerman1*, Menahem Segal2, and Elisha Moses1

1 Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel
2 Neurobiology, Weizmann Institute of Science, Rehovot, Israel

* To whom correspondence should be addressed. E-mail: feiner{at}wisemail.weizmann.ac.il.

Dissociated neurons were cultured on lines of various lengths covered with adhesive material to obtain an experimental model system of linear signal transmission. The neuronal connectivity in the linear culture is characterized, and it is demonstrated that local spiking activity is relayed by synaptic transmission along the line of neurons to develop into a large-scale population burst. Formally, this can be treated as a one-dimensional information channel. Directional propagation of both spontaneous and stimulated bursts along the line, imaged with the calcium indicator Fluo-4, revealed the existence of two different propagation velocities. Initially, a small number of neighboring neurons fire, leading to a slow, small and presumably asynchronous wave of activity. The signal then spontaneously develops to encompass much larger and further populations, and is characterized by fast propagation of high amplitude activity, which is presumed to be synchronous. These results are well described by an existing theoretical model for propagation based on an integrate and fire model (Osan and Ermentrout 2002).




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