JN Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Neurophysiol (July 27, 2005). doi:10.1152/jn.00264.2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
94/5/3406    most recent
00264.2005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Feinerman, O.
Right arrow Articles by Moses, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Feinerman, O.
Right arrow Articles by Moses, E.
Submitted on March 11, 2005
Accepted on July 17, 2005

Signal Propagation along Uni-dimensional Neuronal Networks

Ofer Feinerman1*, Menahem Segal2, and Elisha Moses1

1 Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel
2 Neurobiology, Weizmann Institute of Science, Rehovot, Israel

* To whom correspondence should be addressed. E-mail: feiner{at}wisemail.weizmann.ac.il.

Dissociated neurons were cultured on lines of various lengths covered with adhesive material to obtain an experimental model system of linear signal transmission. The neuronal connectivity in the linear culture is characterized, and it is demonstrated that local spiking activity is relayed by synaptic transmission along the line of neurons to develop into a large-scale population burst. Formally, this can be treated as a one-dimensional information channel. Directional propagation of both spontaneous and stimulated bursts along the line, imaged with the calcium indicator Fluo-4, revealed the existence of two different propagation velocities. Initially, a small number of neighboring neurons fire, leading to a slow, small and presumably asynchronous wave of activity. The signal then spontaneously develops to encompass much larger and further populations, and is characterized by fast propagation of high amplitude activity, which is presumed to be synchronous. These results are well described by an existing theoretical model for propagation based on an integrate and fire model (Osan and Ermentrout 2002).




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
S. Jacobi and E. Moses
Variability and Corresponding Amplitude-Velocity Relation of Activity Propagating in One-Dimensional Neural Cultures
J Neurophysiol, May 1, 2007; 97(5): 3597 - 3606.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
O. Feinerman, M. Segal, and E. Moses
Identification and Dynamics of Spontaneous Burst Initiation Zones in Unidimensional Neuronal Cultures
J Neurophysiol, April 1, 2007; 97(4): 2937 - 2948.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
O. Feinerman and E. Moses
Transport of information along unidimensional layered networks of dissociated hippocampal neurons and implications for rate coding.
J. Neurosci., April 26, 2006; 26(17): 4526 - 4534.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2005 by the The American Physiological Society.