| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Kennedy Krieger Institute, Baltimore, Maryland, United States; Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
2 School of Psychology, University of Wales, Bangor, Bangor, gwynedd, United Kingdom
3 The Neurological Institute, Columbia University College of Physicians and Surgeons, New York, New York, United States
4 Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
* To whom correspondence should be addressed. E-mail: bastian{at}kennedykrieger.org.
The cerebellum is an essential part of the neural network involved in adapting goal-directed arm movements. This adaptation might rely on two distinct signals: a sensory prediction error, or a motor correction. Sensory prediction errors occur when an initial motor command is generated but the predicted sensory consequences do not match the observed values. In some tasks, these sensory errors are monitored and result in online corrective motor output as the movement progresses. Here we asked whether cerebellum-dependent adaptation of reaching relies on sensory or online motor corrections. Healthy controls and people with hereditary cerebellar ataxia reached during a visuomotor perturbation in two conditions: "shooting" movements without online corrections, and "pointing" movements that allowed for online corrections. Sensory (i.e. visual) errors were available in both conditions. Results showed that the addition of motor corrections did not influence adaptation in control subjects, suggesting that only sensory errors were needed for learning. Cerebellar subjects were comparably impaired in both adaptation conditions relative to controls, despite abnormal and inconsistent online motor correction. Specifically, poor online motor corrections were unrelated to cerebellar subjects’ adaptation deficit (i.e. adaptation did not worsen), further suggesting that only sensory prediction errors influence this process. Therefore, adaptation to visuomotor perturbations depends on the cerebellum, and is driven by the mismatch between predicted and actual sensory outcome of motor commands.
This article has been cited by other articles:
|
|
 |
|
  H. Tanaka, T. J. Sejnowski, and J. W. Krakauer Adaptation to Visuomotor Rotation Through Interaction Between Posterior Parietal and Motor Cortical Areas J Neurophysiol, November 1, 2009; 102(5): 2921 - 2932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-M. Bernier, B. Burle, F. Vidal, T. Hasbroucq, and J. Blouin Direct Evidence for Cortical Suppression of Somatosensory Afferents during Visuomotor Adaptation Cereb Cortex, September 1, 2009; 19(9): 2106 - 2113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-Y. Lee and N. Schweighofer Dual Adaptation Supports a Parallel Architecture of Motor Memory J. Neurosci., August 19, 2009; 29(33): 10396 - 10404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kaku, K. Yoshida, and Y. Iwamoto Learning Signals from the Superior Colliculus for Adaptation of Saccadic Eye Movements in the Monkey J. Neurosci., April 22, 2009; 29(16): 5266 - 5275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Rabe, O. Livne, E. R. Gizewski, V. Aurich, A. Beck, D. Timmann, and O. Donchin Adaptation to Visuomotor Rotation and Force Field Perturbation Is Correlated to Different Brain Areas in Patients With Cerebellar Degeneration J Neurophysiol, April 1, 2009; 101(4): 1961 - 1971. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Choi, E. P. G. Vining, D. S. Reisman, and A. J. Bastian Walking flexibility after hemispherectomy: split-belt treadmill adaptation and feedback control Brain, March 1, 2009; 132(3): 722 - 733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Rabe, B. Brandauer, Y. Li, E. R. Gizewski, D. Timmann, and J. Hermsdorfer Size-Weight Illusion, Anticipation, and Adaptation of Fingertip Forces in Patients With Cerebellar Degeneration J Neurophysiol, February 1, 2009; 101(2): 569 - 579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Fishbach and F. A. Mussa-Ivaldi Seeing versus Believing: Conflicting Immediate and Predicted Feedback Lead to Suboptimal Motor Performance J. Neurosci., December 24, 2008; 28(52): 14140 - 14146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. W. Heuer, S. Tokiyama, and S. G. Lisberger Doing Without Learning: Stimulation of the Frontal Eye Fields and Floccular Complex Does Not Instruct Motor Learning in Smooth Pursuit Eye Movements J Neurophysiol, September 1, 2008; 100(3): 1320 - 1331. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
