| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
* To whom correspondence should be addressed. E-mail: yan.rao{at}yale.edu.
In vitro long-term depression (LTD) is thought to be a model for the loss of cortical responsiveness to an eye deprived of vision during the critical period. Using whole-cell recording, the present study investigates the mechanisms of LTD in vitro across layers in developing rat visual cortex. LTD was induced in layer II/III, layer V and layer VI but not layer IV with 10 min 1 Hz stimulation paired with postsynaptic depolarization. LTD in layer II/III and layer V could be blocked by the NMDA receptor antagonist D-AP5, but not by 100 µM LY341495, a metabotropic glutamate receptor inhibitor. In contrast, LTD in layer VI was blocked by 100 µM LY341495 and AIDA but not D-AP5, and partially blocked by application of GDP-
-S in patch pipette, suggesting an involvement of postsynaptic group I mGluRs. These results indicate that LTD in developing rat visual cortex varies with layer: LTD was absent in layer IV, suggesting a unique plasticity mechanism at geniculocortical synapses; LTD in layer II/III and V depends on NMDA receptors but not mGluRs; and LTD in layer VI requires mGluRs but not NMDA receptors.
This article has been cited by other articles:
|
|
 |
|
  B.-J. Yoon, G. B. Smith, A. J. Heynen, R. L. Neve, and M. F. Bear Essential role for a long-term depression mechanism in ocular dominance plasticity PNAS, June 16, 2009; 106(24): 9860 - 9865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Tropea, A. Van Wart, and M. Sur Molecular mechanisms of experience-dependent plasticity in visual cortex Phil Trans R Soc B, February 12, 2009; 364(1515): 341 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B Smith, A. J Heynen, and M. F Bear Bidirectional synaptic mechanisms of ocular dominance plasticity in visual cortex Phil Trans R Soc B, February 12, 2009; 364(1515): 357 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-J. Jang, K.-H. Cho, H.-S. Kim, S. J. Hahn, M.-S. Kim, and D.-J. Rhie Age-Dependent Decline in Supragranular Long-Term Synaptic Plasticity by Increased Inhibition During the Critical Period in the Rat Primary Visual Cortex J Neurophysiol, January 1, 2009; 101(1): 269 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Huang, H. Yasuda, A. Sarihi, and T. Tsumoto Roles of Endocannabinoids in Heterosynaptic Long-Term Depression of Excitatory Synaptic Transmission in Visual Cortex of Young Mice J. Neurosci., July 9, 2008; 28(28): 7074 - 7083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ueta, R. Yamamoto, S. Sugiura, K. Inokuchi, and N. Kato Homer 1a Suppresses Neocortex Long-Term Depression in a Cortical Layer-Specific Manner J Neurophysiol, February 1, 2008; 99(2): 950 - 957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Jiang, M. Trevino, and A. Kirkwood Sequential Development of Long-Term Potentiation and Depression in Different Layers of the Mouse Visual Cortex J. Neurosci., September 5, 2007; 27(36): 9648 - 9652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Crozier, Y. Wang, C.-H. Liu, and M. F. Bear Deprivation-induced synaptic depression by distinct mechanisms in different layers of mouse visual cortex PNAS, January 23, 2007; 104(4): 1383 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Y. Choi, J. Chang, B. Jiang, G.-H. Seol, S.-S. Min, J.-S. Han, H.-S. Shin, M. Gallagher, and A. Kirkwood Multiple Receptors Coupled to Phospholipase C Gate Long-Term Depression in Visual Cortex J. Neurosci., December 7, 2005; 25(49): 11433 - 11443. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
