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J Neurophysiol (October 29, 2003). doi:10.1152/jn.00306.2003
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Submitted on March 28, 2003
Accepted on October 25, 2003

Prefrontal neuronal activity encodes spatial target representations sequentially updated following nonspatial target-shift cues

Tetsuya Fukushima, Isao Hasegawa, and Yasushi Miyashita*

* To whom correspondence should be addressed. E-mail: yasushi_miyashita{at}m.u-tokyo.ac.jp.

We examined prefrontal neuronal activity while monkeys performed a sequential target-shift task, in which, after a positional cue indicated the initial saccade target among eight peripheral positions, the monkeys were required to internally shift the target by one position on every flash of a target-shift cue. The target-shift cue appeared in the center zero to three times within a single trial, and was always the same in shape, size and color. We found selective neuronal activity related to the target position: when the target-shift cue implied the target shift to particular peripheral positions, neurons exhibited early-dominant and late-dominant activity during the following delay period. The early-dominant target-selective activity emerged early in the delay just after the presentation of the target-shift cue, while the late-dominant activity gradually built up toward the end of the delay. Since the target-shift cue was not related to any specific target location, the early-dominant target-selective activity could not be a mere visual response to the target-shift cue. We suggest that the early-dominant activity reflects the transitory representation for the saccade target that was triggered by the nonspatial target-shift cue, whereas the late-dominant activity reflects the target representation in the spatial working memory or the preparatory set for the possible impending saccade, being repeatedly updated during sequential target shifts.




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