JN AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Neurophysiol (June 28, 2006). doi:10.1152/jn.00310.2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
96/5/2501    most recent
00310.2006v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (5)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hofmann, M. E.
Right arrow Articles by Frazier, C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hofmann, M. E.
Right arrow Articles by Frazier, C. J.
Submitted on March 22, 2006
Accepted on June 22, 2006

Endocannabinoid mediated depolarization-induced suppression of inhibition in hilar mossy cells of the rat dentate gyrus

Mackenzie E. Hofmann1, Ben Nahir2, and Charles J. Frazier3*

1 Department of Pharmacodynamics, University of Florida, Gainesville, Florida, United States
2 Department of Neuroscience, University of Florida, Gainesville, Florida, United States
3 Department of Pharmacodynamics, University of Florida, Gainesville, Florida, United States; Department of Neuroscience, University of Florida, Gainesville, Florida, United States

* To whom correspondence should be addressed. E-mail: cjfraz{at}ufl.edu.

Hilar mossy cells represent a unique population of local circuit neurons in the hippocampus and dentate gyrus. Here we use electrophysiological techniques in acute preparations of hippocampal slices to demonstrate that depolarization of a single hilar mossy cell can produce robust inhibition of local GABAergic afferents. This depolarization induced suppression of inhibition (DSI) can be observed as a transient reduction in frequency of spontaneous inhibitory postsynaptic currents (sIPSCs), or as a transient reduction in amplitude of evoked IPSCs. We find that DSI of evoked IPSCs as observed in hilar mossy cells is enhanced by activation of muscarinic acetylcholine receptors, blocked by chelation of postsynaptic calcium, and critically dependent on retrograde activation of presynaptic cannabinoid (CB1) receptors. We further report that activation of CB1 receptors on GABAergic afferents to hilar mossy cells (by either endogenous or exogenous agonists) preferentially inhibits calcium dependent exocytosis, and that endocannabinoid dependent retrograde signalling in this system is subject to tight spatial constraints.




This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
M. Kano, T. Ohno-Shosaku, Y. Hashimotodani, M. Uchigashima, and M. Watanabe
Endocannabinoid-Mediated Control of Synaptic Transmission
Physiol Rev, January 1, 2009; 89(1): 309 - 380.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. Nahir, C. Bhatia, and C. J. Frazier
Presynaptic Inhibition of Excitatory Afferents to Hilar Mossy Cells
J Neurophysiol, June 1, 2007; 97(6): 4036 - 4047.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. L. Howard, A. Neu, R. J. Morgan, J. C. Echegoyen, and I. Soltesz
Opposing Modifications in Intrinsic Currents and Synaptic Inputs in Post-Traumatic Mossy Cells: Evidence for Single-Cell Homeostasis in a Hyperexcitable Network
J Neurophysiol, March 1, 2007; 97(3): 2394 - 2409.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2006 by the The American Physiological Society.