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J Neurophysiol (July 23, 2003). doi:10.1152/jn.00312.2003
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Submitted on March 31, 2003
Accepted on July 16, 2003

Calcium signaling mediated by P2Y receptors in mouse taste cells

Sergey G. Baryshnikov1, Olga A. Rogachevskaja1, and Stanislav S. Kolesnikov1*

1 Institute of Cell Biophysics, Pushchino, Moscow Region, Russian Federation

* To whom correspondence should be addressed. E-mail: staskolesnikov{at}yahoo.com.

Evidence implicates a number of neuroactive substances and their receptors in mediating complex cell-to-cell communications in the taste bud. Recently, we found that ATP, a ubiquitous neurotransmitter/neuromodulator, mobilizes intracellular Ca2+ in taste cells by activating P2Y receptors. Here, P2Y receptor-cellular response coupling was characterized in details using single cell ratio photometry and the inhibitory analysis. The sequence of underlying events was shown to include ATP-dependent activation of PLC, IP3 production, and IP3 receptor mediated Ca2+ release followed by Ca2+ influx. Data obtained favor SOC channels rather than receptor-operated channels as a pathway for Ca2+ influx that accompanies Ca2+ release. Intracellular Ca2+ mobilized by ATP is apparently extruded by the plasma membrane Ca2+-ATPase, while a contribution of the Na+/Ca2+ exchange and other mechanisms of Ca2+ clearance is negligible. Cyclic AMP-dependent phosphorylation is likely to control a gain of the phosphoinositide cascade involved in ATP transduction. ATP-responsive taste cells are abundant in circumvallate, foliate, and fungiform papillae. Taken together, our observations point to a putative role for ATP as a neurotransmitter operative in the taste bud.




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