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J Neurophysiol (May 10, 2006). doi:10.1152/jn.00347.2006
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96/3/1638    most recent
00347.2006v1
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Submitted on April 4, 2006
Accepted on May 8, 2006

High-resolution multi-transistor array recording of electrical field potentials in cultured brain slices

Michael Hutzler1, Armin Lambacher1, Bjoern Eversmann2, Martin Jenkner2, Roland Thewes2, and Peter Fromherz1*

1 Department of Membrane and Neurophysics, Max Planck Institute for Biochemistry, Martinsried/Munich, Germany
2 Corporate Research, Infineon Technologies, Munich, Germany

* To whom correspondence should be addressed. E-mail: fromherz{at}biochem.mpg.de.

We report on the recording of electrical activity in cultured hippocampal slices by a multi-transistor array (MTA) with 16384 elements. Time-resolved imaging is achieved with a resolution of 7.8 µm on an area of 1 mm2 at 2 kHz. A read-out of fewer elements allows an enhanced time resolution. Individual transistor signals are caused by local evoked field potentials. They agree with micropipette measurements in amplitude and shape. The spatial continuity of the records provides time-resolved images of evoked field potentials and allows the detection of functional correlations over large distances. As examples, fast propagating waves of presynaptic action potentials are recorded as well as patterns of excitatory postsynaptic potentials across and along cornu ammonis.




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