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1 Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA
2 Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, NY, USA
* To whom correspondence should be addressed. E-mail: goxford{at}iupui.edu.
Using dissociated rat DRG neurons we have explored the ability of NGF to acutely (within minutes) sensitize responses of nociceptors to capsaicin or noxious heat during postnatal development. While robust sensitization of noxious heat or capsaicin responses by NGF is observed in adult DRG neurons, responses to such stimuli in trkA-positive neurons from early postnatal animals are not sensitized by NGF. Neurons acquire sensitivity to the hyperalgesic effects of NGF between postnatal days 4 and 10 (P4- P10). In contrast to NGF, bradykinin sensitizes responses to noxious heat in both adult and neonatal DRG neurons. These observations suggest a developmental switch in signal transduction cascades linking trkA receptors to hyperalgesia during postnatal development, and differences in the signaling pathways mediating bradykinin- and NGF- induced sensitization.
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