JN AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Neurophysiol (July 7, 2004). doi:10.1152/jn.00376.2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
92/6/3338    most recent
00376.2004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sjostrom, P. J.
Right arrow Articles by Nelson, S. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sjostrom, P. J.
Right arrow Articles by Nelson, S. B.
Submitted on April 13, 2004
Accepted on July 2, 2004

Endocannabinoid-dependent neocortical layer-5 LTD in the absence of postsynaptic spiking

Per J. Sjostrom1, Gina G. Turrigiano2, and Sacha B. Nelson2*

1 Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA, USA; Wolfson Institute for Biomedical Research, University College London, London, United Kingdom
2 Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA, USA

* To whom correspondence should be addressed. E-mail: nelson{at}brandeis.edu.

Long-term depression (LTD) was induced in neocortical layer 5 pyramidal connections by pairing presynaptic firing with subthreshold postsynaptic depolarization (dLTD) or via a spike-timing protocol (tLTD). Like tLTD, dLTD reduced short-term depression and increased the coefficient of variation consistent with a presynaptic site of expression. Also like tLTD, dLTD was blocked by CB1 receptor blockade and required activation of presumably presynaptic NR2B-containing NMDA receptors. The two forms of LTD had identical magnitudes and time courses and occluded one another, and neither depended on frequency. Finally, dLTD shares with tLTD the asymmetric temporal window of induction. In conclusion, the types of LTD induced by these two protocols are indistinguishable, suggesting that the mechanism that underlies tLTD paradoxically does not require postsynaptic spiking: The subthreshold postsynaptic depolarizations of dLTD appear to fully substitute for postsynaptic spiking.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
R. Kellogg, K. Mackie, and A. Straiker
Cannabinoid CB1 Receptor-Dependent Long-Term Depression in Autaptic Excitatory Neurons
J Neurophysiol, August 1, 2009; 102(2): 1160 - 1171.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. A. Parent, L. Wang, J. Su, T. Netoff, and L.-L. Yuan
Identification of the Hippocampal Input to Medial Prefrontal Cortex In Vitro
Cereb Cortex, June 10, 2009; (2009) bhp108v1.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. Kano, T. Ohno-Shosaku, Y. Hashimotodani, M. Uchigashima, and M. Watanabe
Endocannabinoid-Mediated Control of Synaptic Transmission
Physiol Rev, January 1, 2009; 89(1): 309 - 380.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser
Dendritic Excitability and Synaptic Plasticity
Physiol Rev, April 1, 2008; 88(2): 769 - 840.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. A. Farries and A. L. Fairhall
Reinforcement Learning With Modulated Spike Timing Dependent Synaptic Plasticity
J Neurophysiol, December 1, 2007; 98(6): 3648 - 3665.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. L. Hill, T. Gallopin, I. Ferezou, B. Cauli, J. Rossier, P. Schweitzer, and B. Lambolez
Functional CB1 Receptors Are Broadly Expressed in Neocortical GABAergic and Glutamatergic Neurons
J Neurophysiol, April 1, 2007; 97(4): 2580 - 2589.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. R. Hardingham, G. E. Hardingham, K. D. Fox, and J. J. B. Jack
Presynaptic Efficacy Directs Normalization of Synaptic Strength in Layer 2/3 Rat Neocortex After Paired Activity
J Neurophysiol, April 1, 2007; 97(4): 2965 - 2975.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. A. Crozier, Y. Wang, C.-H. Liu, and M. F. Bear
Deprivation-induced synaptic depression by distinct mechanisms in different layers of mouse visual cortex
PNAS, January 23, 2007; 104(4): 1383 - 1388.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
D. A. Fortin and E. S. Levine
Differential Effects of Endocannabinoids on Glutamatergic and GABAergic Inputs to Layer 5 Pyramidal Neurons
Cereb Cortex, January 1, 2007; 17(1): 163 - 174.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Nevian and B. Sakmann
Spine Ca2+ Signaling in Spike-Timing-Dependent Plasticity
J. Neurosci., October 25, 2006; 26(43): 11001 - 11013.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. A. Bender, K. J. Bender, D. J. Brasier, and D. E. Feldman
Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
J. Neurosci., April 19, 2006; 26(16): 4166 - 4177.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
Y. Zilberter, T. Harkany, and C. D. Holmgren
Dendritic Release of Retrograde Messengers Controls Synaptic Transmission in Local Neocortical Networks
Neuroscientist, August 1, 2005; 11(4): 334 - 344.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
A. L. Bodor, I. Katona, G. Nyiri, K. Mackie, C. Ledent, N. Hajos, and T. F. Freund
Endocannabinoid Signaling in Rat Somatosensory Cortex: Laminar Differences and Involvement of Specific Interneuron Types
J. Neurosci., July 20, 2005; 25(29): 6845 - 6856.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2004 by the The American Physiological Society.