JN Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Neurophysiol (October 1, 2003). doi:10.1152/jn.00382.2003
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
91/2/873    most recent
00382.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brown, M. R.
Right arrow Articles by Everling, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brown, M. R.
Right arrow Articles by Everling, S.
Submitted on April 16, 2003
Accepted on September 23, 2003

Comparison of memory- and visually-guided saccades using event-related fMRI

Matthew R. Brown1, Joseph F. DeSouza2, Herb C. Goltz3, Kristen Ford1, Ravi S. Menon4, Melvyn A. Goodale5, and Stefan Everling6*

1 Psychology, University of Western Ontario, London, Ontario, Canada; Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada
2 Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
3 Psychology, University of Western Ontario, London, Ontario, Canada; The Laboratory for Magnetic Resonance Research, Robarts Research Institute, London, Ontario, Canada
4 The Laboratory for Magnetic Resonance Research, Robarts Research Institute, London, Ontario, Canada; Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada
5 Psychology, University of Western Ontario, London, Ontario, Canada; Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada; Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
6 Psychology, University of Western Ontario, London, Ontario, Canada; Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada; The Laboratory for Magnetic Resonance Research, Robarts Research Institute, London, Ontario, Canada

* To whom correspondence should be addressed. E-mail: severlin{at}uwo.ca.

Previous functional imaging studies have shown increased haemodynamic signal in several cortical areas when subjects perform memory-guided saccades compared with visually-guided saccades using blocked trial designs. It is unknown, however, whether this difference results from sensory processes associated with stimulus presentation, from processes occurring during the delay period before saccade generation, or from an increased motor signal for memory-guided saccades. We conducted fMRI using an event-related paradigm that separated stimulus-related, delay-related, and saccade-related activity. Subjects initially fixated a central cross, whose colour indicated whether the trial was a memory- or a visually-guided trial. A peripheral stimulus was then flashed at one of 4 possible locations. On memory-guided trials, subjects had to remember this location for the subsequent saccade, whereas the stimulus was a distractor on visually-guided trials. Fixation cross disappearance after a delay period was the signal either to generate a memory-guided saccade or to look at a visual stimulus that was flashed on visually-guided trials. We found slightly greater stimulus-related activation for visually-guided trials in three right prefrontal regions and right rostral intraparietal sulcus (IPS). Memory-guided trials evoked greater delay-related activity in right posterior inferior frontal gyrus, right medial frontal eye field, bilateral supplementary eye field, right rostral IPS, and right ventral IPS but not in middle frontal gyrus. Right precentral gyrus and right rostral IPS exhibited greater saccade-related activation on memory-guided trials. We conclude that activation differences revealed by previous blocked experiments have different sources in different areas and that cortical saccade regions exhibit delay-related activation differences.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
L. Petit, L. Zago, M. Vigneau, F. Andersson, F. Crivello, B. Mazoyer, E. Mellet, and N. Tzourio-Mazoyer
Functional Asymmetries Revealed in Visually Guided Saccades: An fMRI Study
J Neurophysiol, November 1, 2009; 102(5): 2994 - 3003.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
C.F. Geier, R. Terwilliger, T. Teslovich, K. Velanova, and B. Luna
Immaturities in Reward Processing and Its Influence on Inhibitory Control in Adolescence
Cereb Cortex, October 29, 2009; (2009) bhp225v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. F. Geier, K. Garver, R. Terwilliger, and B. Luna
Development of Working Memory Maintenance
J Neurophysiol, January 1, 2009; 101(1): 84 - 99.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. S. Konen and S. Kastner
Representation of Eye Movements and Stimulus Motion in Topographically Organized Areas of Human Posterior Parietal Cortex
J. Neurosci., August 13, 2008; 28(33): 8361 - 8375.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
U. Ettinger, D. H. ffytche, V. Kumari, N. Kathmann, B. Reuter, F. Zelaya, and S. C. R. Williams
Decomposing the Neural Correlates of Antisaccade Eye Movements Using Event-Related fMRI
Cereb Cortex, May 1, 2008; 18(5): 1148 - 1159.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
C. C. Ruff, S. Bestmann, F. Blankenburg, O. Bjoertomt, O. Josephs, N. Weiskopf, R. Deichmann, and J. Driver
Distinct Causal Influences of Parietal Versus Frontal Areas on Human Visual Cortex: Evidence from Concurrent TMS-fMRI
Cereb Cortex, April 1, 2008; 18(4): 817 - 827.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Kastner, K. DeSimone, C. S. Konen, S. M. Szczepanski, K. S. Weiner, and K. A. Schneider
Topographic Maps in Human Frontal Cortex Revealed in Memory-Guided Saccade and Spatial Working-Memory Tasks
J Neurophysiol, May 1, 2007; 97(5): 3494 - 3507.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. E. Curtis and M. D'Esposito
Selection and Maintenance of Saccade Goals in the Human Frontal Eye Fields
J Neurophysiol, June 1, 2006; 95(6): 3923 - 3927.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Schluppeck, P. Glimcher, and D. J. Heeger
Topographic Organization for Delayed Saccades in Human Posterior Parietal Cortex
J Neurophysiol, August 1, 2005; 94(2): 1372 - 1384.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
S. Tsujimoto and T. Sawaguchi
Context-dependent Representation of Response-outcome in Monkey Prefrontal Neurons
Cereb Cortex, July 1, 2005; 15(7): 888 - 898.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
W. P. Medendorp, H. C. Goltz, J. D. Crawford, and T. Vilis
Integration of Target and Effector Information in Human Posterior Parietal Cortex for the Planning of Action
J Neurophysiol, February 1, 2005; 93(2): 954 - 962.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. E. Curtis, V. Y. Rao, and M. D'Esposito
Maintenance of Spatial and Motor Codes during Oculomotor Delayed Response Tasks
J. Neurosci., April 21, 2004; 24(16): 3944 - 3952.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2003 by the The American Physiological Society.