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J Neurophysiol (September 26, 2007). doi:10.1152/jn.00397.2007
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Submitted on April 6, 2007
Accepted on September 24, 2007

Layer V neurons in mouse cortex projecting to different targets have distinct physiological properties

Alexis M. Hattox1 and Sacha B. Nelson2*

1 Biology Department, Brandeis University, Waltham, Massachusetts, United States
2 Department of Biology, Brandeis University, Waltham, Massachusetts, United States; Biology Department, Brandeis University, Waltham, Massachusetts, United States

* To whom correspondence should be addressed. E-mail: nelsonjnp{at}courier.brandeis.edu.

Layer V pyramidal neurons are anatomically and physiologically heterogeneous and project to multiple intracortical and subcortical targets. However, because most physiological studies of layer V pyramidal neurons have been carried out on unidentified cells, we know little about how anatomical and physiological properties relate to subcortical projection site. Here we combine neuroanatomical tract tracing with whole cell recordings in mouse somatosensory cortex to test whether neurons with the same projection target form discrete subpopulations and whether they have stereotyped physiological properties. Our findings indicate that corticothalamic and corticotrigeminal neurons are two largely non-overlapping subpopulations, while callosal and corticostriatal neurons overlap extensively. The morphology as well as the intrinsic membrane and firing properties of corticothalamic and corticotrigeminal neurons differ from those of callosal and corticostriatal neurons. In addition, we find that each class of projection neuron exhibits a unique compliment of hyperpolarizing and depolarizing afterpotentials that further suggests that cortical neurons with different subcortical targets are distinct from one another.




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