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1 Neuroscience, Erasmus MC, Rotterdam, Netherlands
* To whom correspondence should be addressed. E-mail: g.borst{at}erasmusmc.nl.
We studied the contribution of a change in presynaptic calcium influx to post-tetanic potentiation (PTP) in the calyx of Held synapse, an axosomatic synapse in the auditory brainstem. We made whole-cell patch-clamp recordings of a principal cell following loading of the presynaptic terminal with a calcium dye. After induction of PTP by a high-frequency train of afferent stimuli, the Fluo-4 fluorescence transients evoked by an action potential became on average 15 ± 4% larger (n=7). Model predictions did not match the fluorescence transients evoked by trains of brief calcium currents unless the endogenous calcium buffer had low affinity for calcium, making a contribution of saturation of the endogenous buffer to the synaptic potentiation we observed in the present experiments less likely. Our data therefore suggest that the increase of release probability during PTP at the calyx of Held synapse is largely due to an increase in the calcium influx per action potential.
This article has been cited by other articles:
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  M. Muller, F. Felmy, and R. Schneggenburger A limited contribution of Ca2+ current facilitation to paired-pulse facilitation of transmitter release at the rat calyx of Held J. Physiol., November 15, 2008; 586(22): 5503 - 5520. [Abstract] [Full Text] [PDF]
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 J. S. Lee, M.-H. Kim, W.-K. Ho, and S.-H. Lee Presynaptic Release Probability and Readily Releasable Pool Size Are Regulated by Two Independent Mechanisms during Posttetanic Potentiation at the Calyx of Held Synapse J. Neurosci., August 6, 2008; 28(32): 7945 - 7953. [Abstract] [Full Text] [PDF]
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L. B. Silverman-Gavrila and A. J. Smith Facilitating exchange: activity-dependent regulation of presynaptic Na+/Ca2+ exchange J. Physiol., April 15, 2008; 586(8): 2039 - 2040. [Full Text] [PDF]
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 N. Korogod, X. Lou, and R. Schneggenburger Posttetanic potentiation critically depends on an enhanced Ca2+ sensitivity of vesicle fusion mediated by presynaptic PKC PNAS, October 2, 2007; 104(40): 15923 - 15928. [Abstract] [Full Text] [PDF]
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R. L. P. Habets and J. G. G. Borst Dynamics of the readily releasable pool during post-tetanic potentiation in the rat calyx of Held synapse J. Physiol., June 1, 2007; 581(2): 467 - 478. [Abstract] [Full Text] [PDF]
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M. Muller, F. Felmy, B. Schwaller, and R. Schneggenburger Parvalbumin Is a Mobile Presynaptic Ca2+ Buffer in the Calyx of Held that Accelerates the Decay of Ca2+ and Short-Term Facilitation J. Neurosci., February 28, 2007; 27(9): 2261 - 2271. [Abstract] [Full Text] [PDF]
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 F. Felmy and H. von Gersdorff Late Switch for Post-Tetanic Potentiation: Once Again It's Ca2+. Focus on "An Increase in Calcium Influx Contributes to Post-Tetanic Potentiation at the Rat Calyx of Held Synapse" J Neurophysiol, December 1, 2006; 96(6): 2840 - 2841. [Full Text] [PDF]
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