| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Nijmegen Institute for Cognition and Information, Radboud University Nijmegen, Nijmegen, Netherlands; F.C. Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, Netherlands
2 F.C. Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, Netherlands
3 F.C. Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, Netherlands; Nijmegen Institute for Cognition and Information, Radboud University Nijmegen, Nijmegen, Netherlands
4 Nijmegen Institute for Cognition and Information, Radboud University Nijmegen, Montessorilaan 3, Nijmegen, 6525 HR, Netherlands; F.C. Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, Netherlands
* To whom correspondence should be addressed. E-mail: S.Beurze{at}nici.ru.nl.
To plan a reaching movement, the brain must integrate information about the location of the target with information about the limb selected for the reach. Here, we applied rapid event-related 3-T fMRI to investigate this process in human subjects (n=16) preparing a reach following two successive visual instruction cues. One cue instructed which arm to use; the other cue instructed the location of the reach target. We hypothesized that regions involved in the integration of target and effector information should not only respond to each of the two instruction cues, but should respond more strongly to the second cue due to the added integrative processing to establish the reach plan. We found bilateral regions in the posterior parietal cortex, the premotor cortex, the medial frontal cortex and the insular cortex to be involved in target-arm integration, as well as the left dorsolateral prefrontal cortex and an area in the right lateral occipital sulcus to respond in this manner. We further determined the functional properties of these regions in terms of spatial and effector specificity. This showed that the posterior parietal cortex and the dorsal premotor cortex specify both the spatial location of a target and the effector selected for the response. We therefore conclude that these regions are selectively engaged in the neural computations for reach planning, consistent with the results from physiological studies in non-human primates.
This article has been cited by other articles:
|
|
 |
|
  J. Majdandzic, H. Bekkering, H. T. van Schie, and I. Toni Movement-Specific Repetition Suppression in Ventral and Dorsal Premotor Cortex during Action Observation Cereb Cortex, November 1, 2009; 19(11): 2736 - 2745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Praamstra, D. Kourtis, and K. Nazarpour Simultaneous Preparation of Multiple Potential Movements: Opposing Effects of Spatial Proximity Mediated by Premotor and Parietal Cortex J Neurophysiol, October 1, 2009; 102(4): 2084 - 2095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Duque and R. B. Ivry Role of Corticospinal Suppression during Motor Preparation Cereb Cortex, September 1, 2009; 19(9): 2013 - 2024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Beurze, F. P. de Lange, I. Toni, and W. P. Medendorp Spatial and Effector Processing in the Human Parietofrontal Network for Reaches and Saccades J Neurophysiol, June 1, 2009; 101(6): 3053 - 3062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bedard and J. N. Sanes Gaze and Hand Position Effects on Finger-Movement-Related Human Brain Activation J Neurophysiol, February 1, 2009; 101(2): 834 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Nakayama, T. Yamagata, J. Tanji, and E. Hoshi Transformation of a Virtual Action Plan into a Motor Plan in the Premotor Cortex J. Neurosci., October 8, 2008; 28(41): 10287 - 10297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vesia, X. Yan, D. Y. Henriques, L. E. Sergio, and J. D. Crawford Transcranial Magnetic Stimulation Over Human Dorsal-Lateral Posterior Parietal Cortex Disrupts Integration of Hand Position Signals Into the Reach Plan J Neurophysiol, October 1, 2008; 100(4): 2005 - 2014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Stark and E. Zohary Parietal Mapping of Visuomotor Transformations during Human Tool Grasping Cereb Cortex, October 1, 2008; 18(10): 2358 - 2368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. C. Chang, A. R. Dickinson, and L. H. Snyder Limb-Specific Representation for Reaching in the Posterior Parietal Cortex J. Neurosci., June 11, 2008; 28(24): 6128 - 6140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Verhagen, H. C. Dijkerman, M. J. Grol, and I. Toni Perceptuo-Motor Interactions during Prehension Movements J. Neurosci., April 30, 2008; 28(18): 4726 - 4735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Macaluso, C. D. Frith, and J. Driver Delay Activity and Sensory-Motor Translation During Planned Eye or Hand Movements to Visual or Tactile Targets J Neurophysiol, November 1, 2007; 98(5): 3081 - 3094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Tomassini, S. Jbabdi, J. C. Klein, T. E. J. Behrens, C. Pozzilli, P. M. Matthews, M. F. S. Rushworth, and H. Johansen-Berg Diffusion-Weighted Imaging Tractography-Based Parcellation of the Human Lateral Premotor Cortex Identifies Dorsal and Ventral Subregions with Anatomical and Functional Specializations J. Neurosci., September 19, 2007; 27(38): 10259 - 10269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Jokisch and O. Jensen Modulation of Gamma and Alpha Activity during a Working Memory Task Engaging the Dorsal or Ventral Stream J. Neurosci., March 21, 2007; 27(12): 3244 - 3251. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
