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J Neurophysiol (August 10, 2005). doi:10.1152/jn.00480.2005
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Submitted on May 10, 2005
Accepted on August 4, 2005

Regulation of IPSP theta rhythm by muscarinic receptors and endocannabinoids in hippocampus

Christian G. Reich1, Miranda A. Karson1, Sergei V. Karnup1, Lauren M. Jones1, and Bradley E. Alger1*

1 Physiology, University of Maryland School of Medicine, Baltimore, MD, USA

* To whom correspondence should be addressed. E-mail: balger{at}umaryland.edu.

Theta rhythms are behaviorally relevant electrical oscillations in the mammalian brain, particularly the hippocampus. In many cases, theta oscillations are shaped by inhibitory post-synaptic potentials (IPSPs) that are driven by glutamatergic and/or cholinergic. Here we show that hippocampal theta rhythm IPSPs induced in the CA1 region by muscarinic receptors (mAChRs) independent of all glutamate receptors can be briefly interrupted by action-potential-induced, retrograde endocannabinoid release. Theta IPSPs can be recorded in CA1 pyramidal cell somata surgically isolated from CA3, subiculum and even from their own apical dendrites. These results suggest that perisomatic-targeting interneurons whose output is subject to inhibition by endocannabinoids are the likely source of theta IPSPs. Interneurons having these properties include the CCK-containing cells. Simultaneous recordings from pyramidal cell-pairs reveal synchronous theta-frequency IPSPs in neighboring pyramidal cells, suggesting that these IPSPs may help entrain or modulate small groups of pyramidal cells.




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