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1 Neurobiology and Anatomy, University of Texas medical school at Houston, Houston, Texas, USA; Biomedical Engineering, University of Texas, Austin, Austin, Texas, USA
2 Neurobiology and Anatomy, University of Texas medical school at Houston, Houston, Texas, USA
* To whom correspondence should be addressed. E-mail: harel.shouval{at}uth.tmc.edu.
Theoretical studies have shown that calcium influx through NMDA receptors is a sufficient signal, that can account for various induction protocols of bidirectional synaptic plasticity, including spike time dependent plasticity (STDP) (Karmarkar and Buonomano 2002; Kitajima and Hara 2000; Shouval et al. 2002b). The STDP curves obtained by these different models exhibits a form of spike time dependent long term depression, that occurs when a presynaptic spike precedes the postsynaptic spike (pre-post LTD). We have previously proposed that this novel form of LTD can serve as an experimental test for the validity of these models (Shouval et al. 2002b). These, calcium based, theoretical models assumed deterministic calcium dynamics; that reflect average properties of synaptic calcium currents. In this paper we show that taking into account the stochastic properties of synaptic transmission significantly alters the form of STDP curves, and might significantly reduce the magnitude of pre-post LTD.
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