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* To whom correspondence should be addressed. E-mail: mcl{at}epl.meei.harvard.edu.
The availability of transgenic and mutant lines makes the mouse a valuable model for study of the inner ear, and a powerful window into cochlear function can be obtained via recordings from single auditory nerve (AN) fibers. This study provides the first systematic description of spontaneous and sound-evoked discharge properties of AN fibers in mouse, specifically in CBA/CaJ and C57BL/6 strains, both commonly used in auditory research. Response properties of 196 AN fibers from CBA/CaJ and 58 from C57BL/6 were analyzed, including spontaneous rates (SR), tuning curves, rate-vs-level functions, dynamic range, response adaptation, phase-locking and the relation between SR and these response properties. The only significant inter-strain difference was the elevation of high-frequency thresholds in C57BL/6. In general, mouse AN fibers showed similar responses to other mammals: sharpness of tuning increased with characteristic frequency, which ranged from 2.5 to 70 kHz; SRs ranged from 0 to 120 sp/sec, and fibers with low SR (< 1 sp sec) had higher thresholds, and wider dynamic ranges than fibers with high SR. Dynamic ranges for mouse high-SR fibers were smaller (< 20 dB) than those seen in other mammals. Phase-locking was seen for tone frequencies < 4 kHz. Maximum synchronization indices were lower than those in cat but similar to those found in guinea pig.
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