| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Anatomy and Neurobiology, University of Tennessee, Memphis, TN, USA
* To whom correspondence should be addressed. E-mail: foehring{at}nb.utmem.edu.
We examined the effects of recent discharge activity on [Ca2+]iin neocortical pyramidal cells. Our data confirm and extend the observation (Helmchen et al. 1996) that there is a linear relationship between plateau [Ca2+]iand firing frequency in soma and proximal apical dendrites. The rise in [Ca2+]i activates K+ channels underlying the afterhyperpolarization (AHP), which consists of two Ca2+-dependent components: the medium AHP (mAHP) and the slow AHP (sAHP). The mAHP is blocked by apamin, indicating involvement of SK type Ca2+-dependent K+ channels. The identity of the apamin-insensitive sAHP channel is unknown. We compared the sAHP and the mAHP with regard to: 1) number and frequency of spikes vs. AHP amplitude; 2) number and frequency of spikes vs. [Ca2+]i; 3) IAHP vs. [Ca+]i. Our data suggest that sAHP channels require an elevation of [Ca2+]i in the cytoplasm, rather than at the membrane, consistent with a role for a cytoplasmic intermediate between Ca2+ and the K+ channels. The mAHP channels appear to respond to a restricted Ca2+ domain.
This article has been cited by other articles:
|
|
 |
|
  E. Santini, G. J. Quirk, and J. T. Porter Fear Conditioning and Extinction Differentially Modify the Intrinsic Excitability of Infralimbic Neurons J. Neurosci., April 9, 2008; 28(15): 4028 - 4036. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Kasten, B. Rudy, and M. P. Anderson Differential regulation of action potential firing in adult murine thalamocortical neurons by Kv3.2, Kv1, and SK potassium and N-type calcium channels J. Physiol., October 15, 2007; 584(2): 565 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. W. Hopf, M. Martin, B. T. Chen, M. S. Bowers, M. M. Mohamedi, and A. Bonci Withdrawal From Intermittent Ethanol Exposure Increases Probability of Burst Firing in VTA Neurons In Vitro J Neurophysiol, October 1, 2007; 98(4): 2297 - 2310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chen, J. D. Bohanick, M. Nishihara, J. K. Seamans, and C. R. Yang Dopamine D1/5 Receptor-Mediated Long-Term Potentiation of Intrinsic Excitability in Rat Prefrontal Cortical Neurons: Ca2+-Dependent Intracellular Signaling J Neurophysiol, March 1, 2007; 97(3): 2448 - 2464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Allen, B. Fakler, J. Maylie, and J. P. Adelman Organization and Regulation of Small Conductance Ca2+-activated K+ Channel Multiprotein Complexes J. Neurosci., February 28, 2007; 27(9): 2369 - 2376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. de Sevilla, J. Garduno, E. Galvan, and W. Buno Calcium-Activated Afterhyperpolarizations Regulate Synchronization and Timing of Epileptiform Bursts in Hippocampal CA3 Pyramidal Neurons J Neurophysiol, December 1, 2006; 96(6): 3028 - 3041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kelly and J. Church Relationships Between Calcium and pH in the Regulation of the Slow Afterhyperpolarization in Cultured Rat Hippocampal Neurons J Neurophysiol, November 1, 2006; 96(5): 2342 - 2353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Wilson and J. A. Goldberg Origin of the Slow Afterhyperpolarization and Slow Rhythmic Bursting in Striatal Cholinergic Interneurons J Neurophysiol, January 1, 2006; 95(1): 196 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Manuel, C. Meunier, M. Donnet, and D. Zytnicki How Much Afterhyperpolarization Conductance Is Recruited by an Action Potential? A Dynamic-Clamp Study in Cat Lumbar Motoneurons J. Neurosci., September 28, 2005; 25(39): 8917 - 8923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Gu, K. Vervaeke, H. Hu, and J. F Storm Kv7/KCNQ/M and HCN/h, but not KCa2/SK channels, contribute to the somatic medium after-hyperpolarization and excitability control in CA1 hippocampal pyramidal cells J. Physiol., August 1, 2005; 566(3): 689 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Teruyama and W. E Armstrong Enhancement of calcium-dependent afterpotentials in oxytocin neurons of the rat supraoptic nucleus during lactation J. Physiol., July 15, 2005; 566(2): 505 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. F. Lee, J. C. Callaway, and R. C. Foehring Effects of Temperature on Calcium Transients and Ca2+-Dependent Afterhyperpolarizations in Neocortical Pyramidal Neurons J Neurophysiol, April 1, 2005; 93(4): 2012 - 2020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Jow, Z.-H. Zhang, D. C. Kopsco, K. C. Carroll, and K. Wang Functional coupling of intracellular calcium and inactivation of voltage-gated Kv1.1/Kv{beta}1.1 A-type K+ channels PNAS, October 26, 2004; 101(43): 15535 - 15540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. W. Wu, C. S. Chan, and J. F. Disterhoft Slow Afterhyperpolarization Governs the Development of NMDA Receptor-Dependent Afterdepolarization in CA1 Pyramidal Neurons During Synaptic Stimulation J Neurophysiol, October 1, 2004; 92(4): 2346 - 2356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ghamari-Langroudi and C. W. Bourque Muscarinic Receptor Modulation of Slow Afterhyperpolarization and Phasic Firing in Rat Supraoptic Nucleus Neurons J. Neurosci., September 1, 2004; 24(35): 7718 - 7726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Villalobos, V. G. Shakkottai, K. G. Chandy, S. K. Michelhaugh, and R. Andrade SKCa Channels Mediate the Medium But Not the Slow Calcium-Activated Afterhyperpolarization in Cortical Neurons J. Neurosci., April 7, 2004; 24(14): 3537 - 3542. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
