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1 Division of Visual Science, Yerkes National Primate Research Center, none
* To whom correspondence should be addressed. E-mail: mjmustar{at}rmy.emory.edu.
The dorsolateral pontine nucleus (DLPN) and nucleus reticularis tegmenti pontis (NRTP) comprise obligatory links in the cortico-ponto-cerebellar system supporting smooth pursuit eye movements. We examined the response properties of DLPN and rNRTP neurons during step-ramp smooth pursuit of a small target moving across a dark background. Our neurophysiological studies were conducted in awake, behaving juvenile macaques (Macaca mulatta). We used multiple linear-regression modeling to estimate the relative sensitivities of neurons to eye parameters (position, velocity and acceleration) and retinal-error parameters (position, velocity and acceleration). We found that a large proportion of pursuit-related DLPN neurons primarily code eye-velocity information, while a large proportion of rNRTP neurons primarily code eye-acceleration information. We calculated the relative decrease in variance found when using a 6-component model that included both eye and retinal-error parameters compared to 3-component models that include either eye or retinal-error. These comparisons show that a majority of DLPN (14/20) and rNRTP (17/19) neurons have larger contributions from eye compared to retinal-error parameters (P<0.001, paired t-test). Even though eye motion parameters provide the strongest contributions in a given model, a significant contribution from retinal-error was often present (i.e., > 20% reduction in variance in 6-component model compared to 3-component models). Thus, our results indicate that the DLPN plays a larger role in maintaining steady state smooth pursuit eye-velocity while rNRTP contributes to both the initiation and maintenance of smooth pursuit.
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