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J Neurophysiol (August 27, 2003). doi:10.1152/jn.00654.2003
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Submitted on July 8, 2003
Accepted on August 21, 2003

A Neural Model for Physiological Responses to Frequency and Amplitude Transitions Uncovers Topographical Order in the Auditory Cortex

Alon Fishbach1*, Yehezkel Yeshurun2, and Israel Nelken3

1 Department of Physiology, Northwestern University, Chicago, IL, USA
2 Department of Computer Science, Tel-Aviv University, Tel-Aviv, Israel
3 Department of Physiology, Hadassah Medical School and the Interdisciplinary Center for Neural Computation, Hebrew University, Jerusalem, Israel

* To whom correspondence should be addressed. E-mail: fishbach{at}northwestern.edu.

We characterize primary auditory cortex (AI) units using a neural model for the detection of frequency and amplitude transitions. The model is a generalization of a model for the detection of amplitude transition [Fishbach et al., 2001]. A set of neurons, tuned in the spectro-temporal domain, is created by means of neural delays and frequency filtering. The sensitivity of the model to frequency and amplitude transitions is achieved by applying a two-dimensional rotateable receptive field to the set of spectro-temporally-tuned neurons. We evaluated the model using data recorded in AI of anesthetized ferrets. We show that the model is able to fit the responses of AI units to variety of stimuli, including single tones, delayed 2-tone stimuli and various frequency-modulated tones, using only a small number of parameters. Furthermore, we show that the topographical order in maps of the model parameters is higher than in maps created from response indices extracted directly from the responses to any single stimulus. These results suggest a possible ordered organization of a simple rotateable spectro-temporal receptive field in the mammalian AI.




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