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J Neurophysiol (November 28, 2007). doi:10.1152/jn.00658.2007
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Submitted on June 14, 2007
Accepted on November 26, 2007

Fine detail of neurovascular coupling revealed by spatio-temporal analysis of the hemodynamic response to single whisker stimulation in rat barrel cortex

Jason Berwick1*, David Johnston2, Myles Jones1, John Martindale1, Chris Martin1, Peter Redgrave3, and John Mayhew4

1 Psychology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom
2 United States; Psychology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom
3 Univ Sheffield; Psychology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom; Univ Sheffield, United States
4 University of Sheffield, UK; Psychology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom; University of Sheffield, UK, United States

* To whom correspondence should be addressed. E-mail: j.berwick{at}sheffield.ac.uk.

The spatial resolution of hemodynamic-based neuroimaging techniques, including fMRI, is limited by the degree to which neurons regulate their blood supply on a fine scale. Here, we investigated the spatial detail of neurovascular events with a combination of high spatio-temporal resolution 2-D spectroscopic optical imaging, multi-channel electrode recordings and cytochrome oxidase histology in the rodent whisker barrel field. Following mechanical stimulation of a single whisker, we found two spatially distinct cortical hemodynamic responses: a transient response in the ‘upstream’ branches of surface arteries and a later highly localized increase in blood volume centred on the activated cortical column. Although the spatial representation of this localised response exceeded that of a single ‘barrel’ , the spread of hemodynamic activity accurately reflected the neural response in neighbouring columns rather than being due to a passive ‘overspill’ . These data confirm hemodynamics are cable of providing accurate ‘ single condition’ maps of neural activity.




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