JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Neurophysiol (September 29, 2004). doi:10.1152/jn.00672.2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
93/3/1816    most recent
00672.2004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Taverna, S.
Right arrow Articles by Pennartz, C. M.A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Taverna, S.
Right arrow Articles by Pennartz, C. M.A.
Submitted on July 2, 2004
Accepted on September 23, 2004

Dopamine D1-receptors modulate lateral inhibition between principal cells of the nucleus accumbens

Stefano Taverna1*, Barbara Canciani2, and Cyriel M.A. Pennartz3

1 Graduate School Neurosciences, Amsterdam, The Netherlands; Department of Anatomy, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
2 Department of Anatomy, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
3 Graduate School Neurosciences, Amsterdam, The Netherlands; Swammerdam Institute for Life Sciences, Department of Animal Physiology and Cognitive Neuroscience, University of Amsterdam, Amsterdam, The Netherlands

* To whom correspondence should be addressed. E-mail: s-taverna{at}northwestern.edu.

One of the current hypotheses on dopamine in the physiology of motivation posits that this neurotransmitter regulates filtering and selection of inputs to the nucleus accumbens. The effects of dopamine (100 µM) and the D1-receptor agonist SKF 38393 (20-50 µM) on GABAergic synaptic transmission between pairs of principal cells of rat nucleus accumbens were studied by using simultaneous dual patch-clamp recordings in acutely prepared brain slices. Both compounds attenuated postsynaptic responses induced by presynaptic firing and this effect was reversed by the D1-receptor antagonist SCH 23390 (25 µM). This attenuating effect of dopamine D1 receptors may act to diminish competitive interactions between single projection neurons or ensembles in the nucleus accumbens.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
S. Taverna, E. Ilijic, and D. J. Surmeier
Recurrent Collateral Connections of Striatal Medium Spiny Neurons Are Disrupted in Models of Parkinson's Disease
J. Neurosci., May 21, 2008; 28(21): 5504 - 5512.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. T. Moyer, J. A. Wolf, and L. H. Finkel
Effects of Dopaminergic Modulation on the Integrative Properties of the Ventral Striatal Medium Spiny Neuron
J Neurophysiol, December 1, 2007; 98(6): 3731 - 3748.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. Gustafson, E. Gireesh-Dharmaraj, U. Czubayko, K. T. Blackwell, and D. Plenz
A Comparative Voltage and Current-Clamp Analysis of Feedback and Feedforward Synaptic Transmission in the Striatal Microcircuit In Vitro
J Neurophysiol, February 1, 2006; 95(2): 737 - 752.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2004 by the The American Physiological Society.