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J Neurophysiol (February 23, 2005). doi:10.1152/jn.00689.2004
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Submitted on July 6, 2004
Accepted on February 19, 2005

Depressed Responses of Facilitatory Synapses

Yoav Banitt, Kevan A. Martin, and Idan Segev*

* To whom correspondence should be addressed. E-mail: idan{at}lobster.ls.huji.ac.il.

We show that when temporal summation takes place, depression of post-synaptic responses may ensue when the underlying synaptic conductance change is constant or even facilitatory. We term this phenomenon "apparent depression". Such apparent depression is most notable for slow synaptic conductance change, for high input frequency and when the synapse is located at distal dendritic sites. We show that, when temporal summation ensues, the erroneous estimation of short-term synaptic plasticity arises partially from the conventional measurement of synaptic dynamics at PSP peak time. This can be corrected when measuring overlapping synaptic responses at fixed intervals following stimulus time. Somatic voltage clamp also helps to partially correct for the "apparent depression", but a good model of the neuron can do even better in providing a more accurate view of the underlying synaptic conductances.




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