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1 Center for Neuroscience and Section of Neurobiology Physiology and Behavior, University of California Davis, Davis, CA, USA
* To whom correspondence should be addressed. E-mail: mlsutter{at}ucdavis.edu.
The intensity-tuning of excitatory and suppressive domain frequency response areas (FRAs) was investigated in 230 cat primary auditory cortical (A1) and 92 posterior auditory field (PAF) neurons. Suppressive domains were explored using simultaneous two-tone stimulation with one tone at the best excitatory frequency (BEF). The intensity-tuning of excitatory and suppressive domains were negatively correlated, supporting the hypothesis that inhibitory sidebands are related to excitatory domain intensity tuning. To further test this hypothesis, we compared the slopes of the edges of suppressive bands to the intensity tuning of excitatory domains. Edges of suppressive bands next to excitatory domains had slopes significantly more slanted towards the excitatory area in neurons with intensity tuned excitatory domains. This relationship was not observed for suppressive band edges not next to the excitatory domain (e.g., the lower edge of lower suppressive bands). This indicates that intensity tuning ultimately observed in the excitatory domain results from overlapping excitatory and inhibitory inputs. In combination with results using forward masking (Calford & Semple 1995), our results suggest that there are separate early and late sources of inhibition contributing to cortical frequency response areas, and only the early-stage inhibition contributes to excitatory domain intensity-tuning.
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