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1 Organismal Biology and Anatomy, The University of Chicago, Chicago, IL, USA
* To whom correspondence should be addressed. E-mail: Tech10s{at}techsan.org.
Most mammals modulate respiratory frequency (RF) to dissipate heat (i.e., panting) and avoid heat stroke during hyperthermic conditions. During hyperthermia, the RF of intact mammals increases then declines or ceases (apnea). It has been proposed that this RF modulation depends on the presence of higher brain structures, such as the hypothalamus. However, the direct effects of hyperthermia on the respiratory neural network have not been examined. To address this issue, the respiratory neural network (i.e., ventral respiratory group (VRG)) was isolated in a brainstem preparation taken from the medulla of mice (P0-P6). Integrated population activity, predominated by inspiratory neurons, was recorded extracellularly from VRG neurons. The bath temperature was then heated from 30°C to 40°C, resulting in a biphasic frequency response in VRG activity. Following an initial 6-7 fold increase and subsequent decline, fictive RF was maintained at a frequency that was higher than baseline frequency; at 40°C, the RF was maintained at about 2-4 times that at 30°C. The inspiratory burst amplitude and duration were significantly reduced during hyperthermic conditions. An increase in RF, decrease in VRG burst amplitude and duration also occurred when heating from 37°C to 40°C. Fictive apnea typically occurred during cooling to the control temperature. Further, changes in hypoglossal motor nucleus activity paralleled those of the VRG, suggesting that temperature modulation of the VRG is likely to have a behaviorally relevant impact on respiration. We conclude that the VRG activity itself is modulated during hyperthermia and the respiratory network is particularly sensitive to temperature changes.
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