JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Neurophysiol (November 22, 2006). doi:10.1152/jn.00745.2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
97/2/1621    most recent
00745.2006v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tobler, P.
Right arrow Articles by Schultz, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tobler, P.
Right arrow Articles by Schultz, W.
Submitted on July 19, 2006
Accepted on November 19, 2006

REWARD VALUE CODING DISTINCT FROM RISK ATTITUDE-RELATED UNCERTAINTY CODING IN HUMAN REWARD SYSTEMS

Philippe Tobler1*, John P O'Doherty2, Raymond J. Dolan3, and Wolfram Schultz1

1 Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
2 Wellcome Dept. Cognitive Neurology, Institute of Neurology, London, United Kingdom; Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, California, United States
3 Wellcome Dept. Cognitive Neurology, Institute of Neurology, London, United Kingdom

* To whom correspondence should be addressed. E-mail: pnt21{at}cam.ac.uk.

When deciding between different options, individuals are guided by the expected (mean) value of the different outcomes and by the associated degrees of uncertainty. We used functional magnetic resonance imaging to identify brain activations coding the key decision parameters of expected value (magnitude and probability) separately from uncertainty (statistical variance) of monetary rewards. Participants discriminated behaviorally between stimuli associated with different expected values and uncertainty. Stimuli associated with higher expected values elicited monotonically increasing activations in distinct regions of the striatum, irrespective of different combinations of magnitude and probability. Stimuli associated with higher uncertainty (variance) elicited increasing activations in the lateral orbitofrontal cortex. Uncertainty-related activations covaried with individual risk aversion in lateral orbitofrontal regions and risk-seeking in more medial areas. Furthermore, activations in expected value-coding regions in prefrontal cortex covaried differentially with uncertainty depending on risk attitudes of individual participants, suggesting that separate prefrontal regions are involved in risk aversion and seeking. These data demonstrate the distinct coding in key reward structures of the two basic and crucial decision parameters, expected value and uncertainty.




This article has been cited by other articles:


Home page
 Cogn Affect Behav NeurosciHome page
M. d'Acremont and P. Bossaerts
Neurobiological studies of risk assessment: A comparison of expected utility and mean-variance approaches
Cogn Affect Behav Neurosci, December 1, 2008; 8(4): 363 - 374.
[Abstract] [PDF]

Home page
 Cogn Affect Behav NeurosciHome page
P. N. Tobler, A. Kalis, and T. Kalenscher
The role of moral utility in decision making: An interdisciplinary framework
Cogn Affect Behav Neurosci, December 1, 2008; 8(4): 390 - 401.
[Abstract] [PDF]

Home page
 Cogn Affect Behav NeurosciHome page
A. Kalis, A. Mojzisch, T. S. Schweizer, and S. Kaiser
Weakness of will, akrasia, and the neuropsychiatry of decision making: An interdisciplinary perspective
Cogn Affect Behav Neurosci, December 1, 2008; 8(4): 402 - 417.
[Abstract] [PDF]

Home page
 Cogn Affect Behav NeurosciHome page
N. Shea, K. Krug, and P. N. Tobler
Conceptual representations in goal-directed decision making
Cogn Affect Behav Neurosci, December 1, 2008; 8(4): 418 - 428.
[Abstract] [PDF]

Home page
 Cereb CortexHome page
C.-s. R. Li, H. H.-A. Chao, and T.-W. Lee
Neural Correlates of Speeded as Compared with Delayed Responses in a Stop Signal Task: An Indirect Analog of Risk Taking and Association with an Anxiety Trait
Cereb Cortex, November 25, 2008; (2008) bhn132v2.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. N. Tobler, G. I. Christopoulos, J. P. O'Doherty, R. J. Dolan, and W. Schultz
Neuronal Distortions of Reward Probability without Choice
J. Neurosci., November 5, 2008; 28(45): 11703 - 11711.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
G. Xue, Z. Lu, I. P. Levin, J. A. Weller, X. Li, and A. Bechara
Functional Dissociations of Risk and Reward Processing in the Medial Prefrontal Cortex
Cereb Cortex, October 8, 2008; (2008) bhn147v1.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
H. E.M. den Ouden, K. J. Friston, N. D. Daw, A. R. McIntosh, and K. E. Stephan
A Dual Role for Prediction Error in Associative Learning
Cereb Cortex, September 26, 2008; (2008) bhn161v1.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
E. T. Rolls, C. McCabe, and J. Redoute
Expected Value, Reward Outcome, and Temporal Difference Error Representations in a Probabilistic Decision Task
Cereb Cortex, March 1, 2008; 18(3): 652 - 663.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2006 by the The American Physiological Society.