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1 Inmed, Marseille, France
* To whom correspondence should be addressed. E-mail: khazipov{at}inmed.univ-mrs.fr.
Early in development, cortical networks generate particular patterns of activity that participate in cortical development. The dominant pattern of electrical activity in the neonatal rat neocortex in vivo is a spatially confined spindle-burst. Here, we studied network mechanisms of generation of spindle-bursts in the barrel cortex of neonatal rats using a superfused cortex preparation in vivo. Both spontaneous and sensory-evoked spindle-bursts were present in the superfused barrel cortex. Pharmacological analysis revealed that spindle-burst are driven by glutamatergic synapses with a major contribution of AMPA/kainate receptors, but slight participation of NMDA receptors and gap-junctions. While GABAergic synapses contributed minimally to the pacing the rhythm of spindle-bursts oscillations, surround GABAergic inhibition appeared to be crucial for their compartmentalization. We propose that local spindle-burst oscillations, driven by glutamatergic synapses and spatially-confined by GABAergic synapses contribute to the development of barrel cortex during the critical period of developmental plasticity.
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