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* To whom correspondence should be addressed. E-mail: d.mcalpine{at}ucl.ac.uk.
We investigated spike-frequency adaptation of neurons sensitive to interaural phase disparities (IPDs) in the inferior colliculus (IC) of urethane-anesthetised guinea pigs using a stimulus paradigm designed to exclude the influence of adaptation below the level of binaural integration. The IPD-step stimulus consists of a binaural 3000-ms tone, in which the first 1000 ms is held at a neuron's least favourable (worst) IPD, adapting out monaural components, before being stepped rapidly to a neuron's most favourable (best) IPD for 300 ms. Following some variable interval (1 - 1000 ms), IPD is again stepped to the best IPD for 300 ms, before being returned to a neuron's worst IPD for the remainder of the stimulus. Exponential decay functions fitted to the response to best-IPD steps revealed an average adaptation time constant of 52.9 ± 26.4 ms. Recovery from adaptation to best IPD steps showed an average time constant of 225.5 ± 210.2 ms. Recovery time constants were not correlated with adaptation time constants. During the recovery period, adaptation to a second best-IPD step followed similar kinetics to adaptation during the first best-IPD step. The mean adaptation time constant at stimulus onset (at worst IPD) was 34.8 ± 19.7 ms, similar to the 38.4 ± 22.1 ms recorded to contralateral stimulation alone. Individual time constants following stimulus onset were correlated with each other but not with time constants during the best-IPD step. We conclude that such binaurally-derived measures of adaptation reflect processes that occur above the level of exclusively monaural pathways, and subsequent to the site of primary binaural interaction.
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