| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
2 Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina, United States
3 Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States; Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
* To whom correspondence should be addressed. E-mail: povyshevanv{at}upmc.edu.
Current dogma holds that a canonical cortical circuit is formed by cellular elements that are basically identical across species. However, detailed and direct comparisons between species of specific elements of this circuit are limited in number. In this study, we compared the morphological and physiological properties of neurogliaform (NGF) inhibitory neurons in the prefrontal cortex (PFC) of macaque monkeys and rats. In both species, NGF cells were readily identified based on their distinctive morphological features. Indeed, monkey NGF cells had only a few morphological features that differed from rat, including a larger soma, a greater number of dendrites, and a more compact axonal field. In contrast, whole-cell recordings of the responses to injected current steps revealed important differences between monkey and rat NGF cells. Monkey NGF cells consistently generated a short-latency first spike riding on an initial depolarization hump, whereas in rat NGF cells, the first spike appeared after a substantial delay riding on a depolarizing ramp not seen in monkey NGF cells. Thus, although rat NGF cells are traditionally classified as late-spiking cells, monkey NGF cells did not meet this physiological criterion. In addition, NGF cells in monkey appeared to be more excitable than those in rat, because they displayed a higher input resistance, a lower spike threshold and a higher firing frequency. Finally, NGF cells in monkey showed a more prominent spike frequency adaptation as compared to rat. Our findings indicate that the canonical cortical circuit differs in at least some aspects of its constituent elements across species.
This article has been cited by other articles:
|
|
 |
|
  A. V. Zaitsev, N. V. Povysheva, G. Gonzalez-Burgos, D. Rotaru, K. N. Fish, L. S. Krimer, and D. A. Lewis Interneuron Diversity in Layers 2-3 of Monkey Prefrontal Cortex Cereb Cortex, July 1, 2009; 19(7): 1597 - 1615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Helmstaedter, B. Sakmann, and D. Feldmeyer L2/3 Interneuron Groups Defined by Multiparameter Analysis of Axonal Projection, Dendritic Geometry, and Electrical Excitability Cereb Cortex, April 1, 2009; 19(4): 951 - 962. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Karagiannis, T. Gallopin, C. David, D. Battaglia, H. Geoffroy, J. Rossier, E. M. C. Hillman, J. F. Staiger, and B. Cauli Classification of NPY-Expressing Neocortical Interneurons J. Neurosci., March 18, 2009; 29(11): 3642 - 3659. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Gonzalez-Burgos, D. C. Rotaru, A. V. Zaitsev, N. V. Povysheva, and D. A. Lewis GABA Transporter GAT1 Prevents Spillover at Proximal and Distal GABA Synapses Onto Primate Prefrontal Cortex Neurons J Neurophysiol, February 1, 2009; 101(2): 533 - 547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. V. Povysheva, A. V. Zaitsev, D. C. Rotaru, G. Gonzalez-Burgos, D. A. Lewis, and L. S. Krimer Parvalbumin-Positive Basket Interneurons in Monkey and Rat Prefrontal Cortex J Neurophysiol, October 1, 2008; 100(4): 2348 - 2360. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
