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1 Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel
2 Department of Physiology, Hebrew University, Jerusalem, Israel
3 Division of Biology, California Institute of Technology, Pasadena, United States
4 Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel; Department of Physiology, Hebrew University, Jerusalem, Israel
* To whom correspondence should be addressed. E-mail: abelesm{at}mail.biu.ac.il.
Despite many reports indicating the existence of precise firing sequences in cortical activity, serious objections have been raised regarding the statistics used to detect them and the relations of these sequences to behavior. We show that in behaving monkeys, pairs of spikes from different neurons tend to prefer certain time delays when measured in relation to a specific behavior. Single unit activity was recorded from 8 microelectrodes inserted into the motor and premotor cortices of two monkeys while they were performing continuous drawing-like hand movements. Repeated scribbling paths, termed drawing components, were extracted by data-mining techniques. The set of the least predictable relations between drawing-components and pairs of neurons was determined and represented by one statistic termed the relations-score. The chance probability of the relations-score was evaluated by teetering the spike times. 1000 surrogates were generated by randomly teetering the original time of each spike in a small window. In 9 out of 13 experimental days the precision was better than 12ms, and in the best case spike precision reached 0.5 milliseconds.
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