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J Neurophysiol (October 29, 2003). doi:10.1152/jn.00802.2003
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Submitted on August 18, 2003
Accepted on October 27, 2003

Quantification of the Factors that Influence Discharge Correlation in Model Motor Neurons

Anna M. Taylor1 and Roger M. Enoka1*

1 Integrative Physiology, University of Colorado, Boulder, CO, USA

* To whom correspondence should be addressed. E-mail: roger.enoka{at}colorado.edu.

The purpose of this study was to quantify the influence of intrinsic properties, active dendritic conductances, and background excitation and inhibition on measures of discharge correlation in the time and frequency domains with known levels and patterns of common synaptic input. The study involved a computer simulation of a population of neurons with a range of input resistances (0.54-3.7 M{Omega}) and surface areas (407,000-712,000 µm2). The neurons were simulated with no, moderate, or high levels of active dendritic conductances and were activated with either excitatory input only or excitatory and inhibitory inputs. The patterns of common input, either branched common input or common modulation, were tested with 0, 30, 60, and 90% common input. The results confirm previous findings (Binder and Powers 2001) of an exponential relation between the level of common input and indexes of synchronization; only when the common input comprised 60% or greater of the total excitatory input was there a significant effect on discharge correlation. Synchronization was greatest in models that had passive dendrites. Active dendritic conductances caused the discharge rate of the neuron to saturate and decreased motor unit synchronization. However, the addition of 10% background inhibitory input increased synchronization in these models. In contrast, common rhythmic modulation of inputs at 24 Hz usually decreased synchronization. Significant coherence at the modulated frequency occurred in the commonly modulated neurons when at least 60% of the inputs were modulated. Furthermore, active dendritic conductances decreased coherence. Branched common input caused high levels of coherence across a broad spectrum, and when combined with active dendritic conductances caused significant frequency peaks in the 30-50 Hz band. In conclusion, the level of inhibitory input and active dendritic conductances interacts with the amount of common input to determine time- and frequency-domain discharge correlation.




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