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J Neurophysiol (October 30, 2002). doi:10.1152/jn.00819.2002
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Submitted on September 17, 2002
Accepted on October 23, 2002

Effects of Unilateral Vestibular Deafferentation on the Linear Vestibulo-Ocular Reflex Evoked by Impulsive Eccentric Roll Rotation

Swee T Aw1*, Michael J Todd1, Leigh A McGarvie1, Americo A Migliaccio1, and Gabor M Halmagyi1

1 Neurology, Royal Prince Alfred Hospital, Sydney, NSW, Australia

* To whom correspondence should be addressed. E-mail: sweea{at}icn.usyd.edu.au.

The effects of unilateral vestibular deafferentation (UVD) on the linear vestibulo-ocular reflex (LVOR) were studied by measuring three-dimensional eye movements in 7 UVD subjects evoked by impulsive eccentric roll rotation while viewing an earth-fixed target at 200, 300 or 600 mm, and comparing their responses to 11 normal subjects. The stimulus, a whole-body roll of ~1°, with the eye positioned 815 mm eccentric to the rotation axis, produced an inter-aural linear acceleration of ~0.5g and a roll acceleration of ~360 °/s2. The responses generated by the LVOR comprise horizontal eye rotations. Horizontal eye velocity at 100 ms from stimulus onset in UVD subjects was significantly lower than in normal subjects for all viewing distances, with no significant difference between ipsilesional and contralesional responses. LVOR acceleration gain, defined as the slope of actual horizontal eye velocity divided by the slope of ideal horizontal eye velocity during a 30 ms period starting 70 ms from stimulus onset, was bilaterally, significantly reduced in UVD subjects at all viewing distances. Acceleration gain from all viewing distances was 1.04 ± 0.28 in normal subjects, and in UVD subjects was 0.49 ± 0.23 for ipsilesional and 0.63 ± 0.27 for contralesional acceleration. LVOR enhancement in the first 100 ms by near viewing was still present in UVD subjects. LVOR latency in in UVD subjects (~39 ms) was not significantly different from normal subjects (~36 ms). After UVD, LVOR is bilaterally and largely symmetrically reduced, but latency remains unchanged and modulation by viewing distance is still present.




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