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1 Biomedical Engineering Program, University of Connecticut, Storrs, CT, USA
2 W. M. Keck Center for Integrative Neuroscience, University of California, San Francisco, CA, USA
3 Biomedical Engineering Program, University of Connecticut, Storrs, CT, USA; Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT, USA
* To whom correspondence should be addressed. E-mail: escabi{at}engr.uconn.edu.
The spectro-temporal receptive field (STRF) is a model representation of the salient excitatory and inhibitory neuronal inputs that shape auditory neuronal preferences. Here we report the properties of monaural STRFs and the relationship between ipsi- and contralateral inputs to neurons in the central nucleus of the inferior colliculus (ICC) of cats. First, we introduce an optimal singular value decomposition method to approximate auditory STRFs as a sum of time-frequency separable Gabor functions. This procedure extracts nine physiologically meaningful parameters and allows us to study the detailed arrangement of the STRF. The STRFs of approximately 60% of colliculus neurons are well described by a time-frequency separable Gabor STRF model, whereas the remaining neurons exhibited obliquely oriented or multiple excitatory/inhibitory subfields that require a nonseparable fitting procedure. Parametric analysis reveals distinct spectro-temporal tradeoffs in receptive field size and modulation filtering resolution. Comparisons between an identical model used to study the spatio-temporal preferences of visual neurons further shows that auditory and visual STRFs share numerous structural properties. We then use the Gabor STRF model to compare quantitatively receptive field properties of contra- and ipsilateral inputs to the ICC. We show that most interaural STRF parameters are highly correlated bilaterally, however, the spectral and temporal phases of ipsi- and contralateral STRFs often differ significantly. Thus, neuronal inputs from each ear share various spectro-temporal response properties, such as their temporal delay, bandwidth, and center frequency but have shifted or interleaved patterns of excitation and inhibition. These differences in converging monaural receptive fields expand binaural processing capacity beyond interaural time and intensity aspects and may enable colliculus neurons to detect disparities in the spectro-temporal composition of the binaural input.
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