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J Neurophysiol (December 17, 2003). doi:10.1152/jn.00900.2003
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Submitted on September 15, 2003
Accepted on December 11, 2003

Equalization of Synaptic Efficacy by Activity- and Timing-Dependent Synaptic Plasticity

Clifton C. Rumsey1* and L. F. Abbott1

1 Volen Center for Complex Systems and Department of Biology, Brandeis University, Waltham, Massachusetts, USA

* To whom correspondence should be addressed. E-mail: rumsey{at}brandeis.edu.

In many neurons, synapses increase in strength as a function of distance from the soma in a manner that appears to compensate for dendritic attenuation. This phenomenon requires a cooperative interaction between local factors that control synaptic strength, such as receptor density and vesicle release probability, and global factors that affect synaptic efficacy, such as attenuation and boosting by active membrane conductances. Anti-STDP, a form of spike-timing dependent synaptic plasticity, in combination with non-associative synaptic potentiation, can accomplish this feat, even though it acts locally and independently at individual synapses. Analytic computations and computer simulations show that this combination of synaptic plasticity mechanisms equalizes the efficacy of synapses over an extended dendritic cable by adjusting local synaptic strengths to compensate for global attenuation.




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