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J Neurophysiol (October 16, 2002). doi:10.1152/jn.00909.2002
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00909.2002v1
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Submitted on October 11, 2002
Accepted on October 13, 2002

Stretch Responses of Cutaneous RA Afferent Neurons in Mouse Hairy Skin

Zaccaria Del Prete1, Stephen P Baker2, and Peter Grigg3*

1 Mechanical Engineering and Aeronautics, University of Rome 'La Sapienza', Rome, Italy
2 Academic Computing, University of Massachusetts Medical School, Worcester, MA, USA
3 Physiology, University of Massachusetts Medical School, Worcester, MA, USA

* To whom correspondence should be addressed. E-mail: peter.grigg{at}umassmed.edu.

Rapidly adapting, stretch sensitive neurons were recorded in vitro, using an isolated preparation of skin and nerve from mouse hindlimb. The skin was stretched uniaxially using a pseudo Gaussian noise (PGN) stimulus. Loads and displacements were recorded as were spike responses of single RA afferent neurons. The goal was to determine what components of the mechanical stimulus were associated with spike responses. The association between stimuli and spike responses was measured using multiple logistic regression. Spike responses were strongly associated with the rate of change of stress, and weakly associated with the rate of change of strain and with stress. There was no association between spike responses and strain. There were significant memory effects associated with each variable, and memory effects differed for each variable. The maximal effect of the rate of change of stress was observed at 8 - 12 ms prior to a spike.




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