| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Physiology and Neuroscience, New York University, School of Medicine, New York, NY, USA
2 Physiology and Neuroscience, New York University, School of Medicine, New York, NY, USA; Rusk Institute, New York University, School of Medicine, New York, NY, USA
* To whom correspondence should be addressed. E-mail: lange01{at}popmail.med.nyu.edu.
Purkinje cells generate simultaneous complex spikes as a result of olivocerebellar activity. This synchronization (to within 1 ms) is thought to result from electrotonic coupling of inferior olivary neurons. Yet, the distance from the inferior olive (IO) varies across the cerebellar cortex. Thus, signals generated simultaneously at the IO should arrive asynchronously across the cerebellar cortex, unless the length differences are compensated for. Previously, it was shown that the conduction time from the IO to the cerebellar cortex remains nearly constant at 
4 ms in the rat, implying the existence of such compensatory mechanisms. Here, we examined the role of myelination in generating a constant olivocerebellar conduction time by investigating the latency of complex spikes evoked by IO stimulation during development in normal rats and myelin deficient mutants. In normal rats, myelination not only reduced overall olivocerebellar conduction time, but also disproportionately reduced the conduction time to vermal lobules, which had the longest response latencies prior to myelination. The net result was a nearly uniform conduction time. In contrast, in myelin-deficient rats, conduction time differences to different parts of the cerebellum remained during the same developmental period. Thus, myelination is the primary factor in generating a uniform olivocerebellar conduction time. To test the importance of a uniform conduction time for generating synchronous complex spike activity, multiple electrode recordings were obtained from normal and myelin deficient rats. Average synchrony levels were higher in normal rats than mutants. Thus, the uniform conduction time achieved through myelination of olivocerebellar fibers appears to be essential for the normal expression of complex spike synchrony.
This article has been cited by other articles:
|
|
 |
|
  T. Chomiak, S. Peters, and B. Hu Functional Architecture and Spike Timing Properties of Corticofugal Projections From Rat Ventral Temporal Cortex J Neurophysiol, July 1, 2008; 100(1): 327 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P Plaha, S Khan, and S S Gill Bilateral stimulation of the caudal zona incerta nucleus for tremor control J. Neurol. Neurosurg. Psychiatry, May 1, 2008; 79(5): 504 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Herzog, W. Hamel, R. Wenzelburger, M. Potter, M. O. Pinsker, J. Bartussek, A. Morsnowski, F. Steigerwald, G. Deuschl, and J. Volkmann Kinematic analysis of thalamic versus subthalamic neurostimulation in postural and intention tremor Brain, June 1, 2007; 130(6): 1608 - 1625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Lang, R. Llinas, and I. Sugihara Isochrony in the olivocerebellar system underlies complex spike synchrony J. Physiol., May 15, 2006; 573(1): 277 - 279. [Full Text] [PDF]
|
|
|
|
|
|
M. R. Baker and S. A. Edgley Reply from M. R. Baker and S. A. Edgley J. Physiol., May 15, 2006; 573(1): 281 - 282. [Full Text] [PDF]
|
|
|
|
|
|
M. R. Baker and S. A. Edgley Non-uniform olivocerebellar conduction time in the vermis of the rat cerebellum J. Physiol., February 1, 2006; 570(3): 501 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ariel Latencies of Climbing Fiber Inputs to Turtle Cerebellar Cortex J Neurophysiol, February 1, 2005; 93(2): 1042 - 1054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Borhegyi, V. Varga, N. Szilagyi, D. Fabo, and T. F. Freund Phase Segregation of Medial Septal GABAergic Neurons during Hippocampal Theta Activity J. Neurosci., September 29, 2004; 24(39): 8470 - 8479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Lyons, C. Yang, S. Eliez, A. L. Reiss, and A. F. Schatzberg Cognitive Correlates of White Matter Growth and Stress Hormones in Female Squirrel Monkey Adults J. Neurosci., April 7, 2004; 24(14): 3655 - 3662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. V. Swindale Neural Synchrony, Axonal Path Lengths, and General Anesthesia: A Hypothesis Neuroscientist, December 1, 2003; 9(6): 440 - 445. [Abstract] [PDF]
|
|
|
|
|
|
D. A. Nicholson and J. H. Freeman Jr. Developmental Changes in Evoked Purkinje Cell Complex Spike Responses J Neurophysiol, October 1, 2003; 90(4): 2349 - 2357. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
