JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Neurophysiol (November 8, 2006). doi:10.1152/jn.00957.2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
97/1/572    most recent
00957.2006v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bennet, L.
Right arrow Articles by Gunn, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bennet, L.
Right arrow Articles by Gunn, A. J.
Submitted on September 7, 2006
Accepted on October 30, 2006

Differential effects of hypothermia on early and late epileptiform events after severe hypoxia in preterm fetal sheep

Laura Bennet1, Justin M. Dean2, Guido Wassink2, and Alistair Jan Gunn3*

1 Department of Physiology, The University of Auckland, Faculty of Medical + Health Sciences, Auckland, New Zealand
2 Physiology, University of Auckland, Auckland, New Zealand
3 Physiology, The University of Auckland, Auckland, New Zealand

* To whom correspondence should be addressed. E-mail: aj.gunn{at}auckland.ac.nz.

Moderate cerebral hypothermia is consistently neuroprotective after experimental hypoxia-ischemia; however, its mechanisms remain poorly defined. Using a model of complete umbilical cord occlusion for 25 min in 0.7 gestation fetal sheep, we examined the effects of cerebral hypothermia (fetal extradural temperature reduced from 39.5±0.2°C to less than 34°C), from 90 min to 70 h after the end of the insult, on post-occlusion epileptiform activity. In the first 6 h after the end of occlusion fetal EEG activity was abnormal with a mixture of fast and slow epileptiform transients superimposed on a suppressed background; seizures started a mean of 8 h after occlusion. There was a close correlation between numbers of these EEG transients and subsequent neuronal loss in the striatum after 3 days recovery (r2=0.65, P=0.008). Hypothermia was associated with a marked reduction in numbers of epileptiform transients in the first 6 h, reduced amplitude of seizures and reduced striatal neuronal loss. In conclusion, neuroprotection with delayed, prolonged head cooling after a severe asphyxial insult in the preterm fetus was associated with potent, specific suppression of epileptiform transients in the early recovery phase, but not of numbers of delayed seizures.




This article has been cited by other articles:


Home page
 PediatricsHome page
S. Shankaran, A. Pappas, A. R. Laptook, S. A. McDonald, R. A. Ehrenkranz, J. E. Tyson, M. Walsh, R. N. Goldberg, R. D. Higgins, A. Das, et al.
Outcomes of Safety and Effectiveness in a Multicenter Randomized, Controlled Trial of Whole-Body Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy
Pediatrics, October 1, 2008; 122(4): e791 - e798.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Bennet, L. C. Booth, N. Ahmed-Nasef, J. M. Dean, J. Davidson, J. S. Quaedackers, and A. J. Gunn
Male disadvantage? Fetal sex and cardiovascular responses to asphyxia in preterm fetal sheep
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1280 - R1286.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2006 by the The American Physiological Society.